Histone cluster 4 H4 Activators
Histone cluster 4 H4 Activators are a collection of chemical compounds that promote the acetylation and subsequent activation of Histone cluster 4 H4, leading to the relaxation of chromatin and facilitation of transcription. Sodium butyrate, Trichostatin A, Valproic acid, SAHA, Nicotinamide, Anacardic acid, Curcumin, Resveratrol, and Panobinostat all function as inhibitors of histone deacetylases (HDACs). These HDAC inhibitors prevent the removal of acetyl groups from lysine residues on Histone cluster 4 H4, maintaining a state of hyperacetylation. Hyperacetylated Histone cluster 4 H4 is associated with an open chromatinstructure, which increases the accessibility of transcription factors to DNA, thus enhancing gene expression. Moreover, Bromodomain inhibitor JQ1 and I-CBP112 disrupt the recognition and binding of acetylated lysine residues on Histone cluster 4 H4 by inhibiting bromodomain-containing proteins such as BET proteins and the CREB binding protein (CBP)/p300, respectively. This disruption further enhances the activation of transcriptional processes that require an open chromatin state.
Additionally, cyclic AMP (cAMP) serves as a second messenger that activates protein kinase A (PKA), which can phosphorylate Histone cluster 4 H4. Phosphorylation of H4 is another post-translational modification that can influence nucleosome remodeling and transcriptional activation, further contributing to the overall enhancement of gene expression mediated by Histone cluster 4 H4. These activators, through their varied mechanisms, ensure the maintenance of Histone cluster 4 H4 in an active state, facilitating the expression of genes in a regulated manner. Collectively, these chemical compounds contribute to the modulation of epigenetic landscapes by ensuring Histone cluster 4 H4 remains conducive to transcriptional activation, thereby influencing cellular processes and gene expression patterns without requiring upregulation of HIST1H4A gene transcription or direct activation of the protein itself.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a histone deacetylase (HDAC) inhibitor. By inhibiting HDAC activity, it leads to an accumulation of acetylated histones, including Histone cluster 4 H4. Acetylation of H4 weakens the interaction of DNA with histones, thus enhancing transcriptional activation and gene expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is another HDAC inhibitor that prevents deacetylation of Histone cluster 4 H4. This leads to a hyperacetylated state of H4, which is associated with an open chromatin structure and increased gene transcription. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid is a short-chain fatty acid that acts as an HDAC inhibitor. By inhibiting deacetylase activity, Valproic acid increases the acetylation levels of H4, enhancing chromatin relaxation and gene expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA is an HDAC inhibitor that increases Histone cluster 4 H4 acetylation, resulting in the relaxation of chromatin structure and facilitation of transcription factor access to DNA. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide is an inhibitor of the sirtuin family of NAD+-dependent HDACs. It indirectly enhances the acetylation of Histone cluster 4 H4, leading to transcriptional activation. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Anacardic acid inhibits p300 histone acetyltransferase, which regulates the acetylation of Histone cluster 4 H4. Inhibition of the deacetylation process indirectly maintains H4 in an acetylated and active state. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a natural compound that possesses HDAC inhibitory activity. It thereby maintains Histone cluster 4 H4 in an acetylated state, promoting gene transcription. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has been shown to inhibit class III HDACs (sirtuins). This contributes to the enhanced acetylation and activation of Histone cluster 4 H4, promoting gene expression. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Panobinostat is a potent HDAC inhibitor. It increases the acetylation levels of Histone cluster 4 H4, leading to an open chromatin state and active transcription. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 is a bromodomain and extra-terminal (BET) protein inhibitor that disrupts the recognition of acetylated lysines on Histone cluster 4 H4. This results in the displacement of BET proteins from chromatin, enhancing gene activation. | ||||||