Hec1 Activators
The chemical class denoted as Hec1 Activators comprises small molecules that indirectly impact the activity of Hec1 through the modulation of cellular mechanisms involved in the regulation of mitosis and kinetochore function. These compounds operate through various biochemical pathways that converge on the cell cycle and chromosomal segregation processes, thereby influencing Hec1 activity, which is central to kinetochore-microtubule attachments. The small molecules listed have distinct targets, such as microtubule dynamics, kinesin motors, kinase activity, and the proteasome, all of which are critical for the proper function and regulation of mitosis. By affecting these pathways, the compounds can lead to an upregulation of Hec1 activity as part of the cellular response to ensure accurate chromosome alignment and segregation.
For instance, compounds like Paclitaxel and Nocodazole affect microtubule stability, an essential component of the spindle apparatus, leading to enhanced kinetochore tension and potentially increased Hec1 activity to maintain chromosome stability. Inhibitors such as Monastrol and S-Trityl-L-cysteine target the kinesin Eg5, causing mitotic arrest that necessitates the role of Hec1 in the spindle assembly checkpoint. Aurora kinase inhibitors, like ZM447439 and Alisertib, and Polo-like kinase inhibitor BI 2536 mediate their effects by altering phosphorylation states within the kinetochore complex, which can modulate Hec1's role in chromosome segregation. The proteasome inhibitor MG-132 indirectly affects Hec1 by stabilizing cell cycle regulators that interact with the spindle assembly checkpoint. Each of these chemicals, by influencing the pathways and processes that are integral to mitosis, can lead to the indirect activation of Hec1, emphasizing their role as Hec1 Activators despite the absence of direct biochemical interaction.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel (Taxol) stabilizes microtubules and prevents their depolymerization, which indirectly impacts Hec1 by increasing the tension and attachment fidelity at the kinetochore-microtubule interface, a key checkpoint for mitotic progression. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a kinesin Eg5 inhibitor which arrests cells in mitosis by disrupting the formation of the bipolar spindle. This can result in increased activity of mitotic checkpoint proteins, including Hec1. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
S-Trityl-L-cysteine is another inhibitor of kinesin Eg5 and functions similarly to Monastrol. It leads to spindle assembly checkpoint activation which may increase Hec1 activity due to heightened checkpoint control during mitosis. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule-depolymerizing agent that activates spindle assembly checkpoint proteins, potentially leading to increased Hec1 activity as the cell monitors proper kinetochore-microtubule attachment. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor that can lead to the accumulation of cell cycle regulators, indirectly affecting Hec1's role in the spindle assembly checkpoint due to the accumulation of proteins that regulate mitosis and kinetochore function. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM447439 is an Aurora kinase inhibitor that, by inhibiting Aurora B, may impact the tension-sensing function of the kinetochore and thus affect Hec1 activity, given Hec1's role in proper chromosome alignment and segregation during mitosis. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
BI 2536, a Polo-like kinase 1 (Plk1) inhibitor, can lead to mitotic arrest and could increase the activity of mitotic checkpoint proteins, including Hec1, by interfering with spindle formation and kinetochore-microtubule attachment fidelity. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $72.00 $297.00 | 4 | |
Purvalanol A is a cyclin-dependent kinase inhibitor (CDK inhibitor) and could indirectly affect Hec1 by altering CDK activity, which is essential for cell cycle progression and, by extension, the proper function of the spindle assembly checkpoint. | ||||||
Tozasertib | 639089-54-6 | sc-358750 sc-358750A | 25 mg 50 mg | $62.00 $87.00 | 4 | |
VX-680 (Tozasertib) is an Aurora kinase inhibitor that can indirectly affect Hec1 activity by influencing the kinetochore function during mitosis through the modification of Aurora kinase-mediated phosphorylation events. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
Alisertib is an inhibitor of Aurora A kinase. Its role in modulating the activity of Aurora kinase can indirectly impact Hec1 by affecting the kinetochore-microtubule attachment process during mitosis. | ||||||