Date published: 2026-4-24

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Hec1 Inhibitors

Hec1 inhibitors belong to a distinct chemical class that has garnered significant attention in the field of biochemical research. These inhibitors are characterized by their ability to selectively target and modulate the activity of the Hec1 protein, a key component of the cellular machinery involved in the proper alignment and separation of chromosomes during cell division. The Hec1 protein plays a pivotal role in ensuring the accurate distribution of genetic material to daughter cells, and any dysregulation in its function can lead to severe genomic instability. Hec1 inhibitors are designed to specifically interact with the Hec1 protein, thereby disrupting its normal function and impeding the precise segregation of chromosomes. Through their intricate chemical structure and targeted mode of action, Hec1 inhibitors offer researchers a powerful tool to investigate the fundamental mechanisms underlying chromosome segregation. Their unique properties make them invaluable in studying cellular processes such as mitosis, providing valuable insights into the intricate orchestration of events necessary for cell division. By unraveling the intricacies of Hec1 inhibition, scientists can shed light on the molecular pathways that govern chromosome segregation and uncover novel strategies for interventions in the future.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1

sc-221711
10 mg
$500.00
(0)

Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1, is a selective inhibitor that disrupts the Hec1/Nek2 signaling axis, crucial for mitotic progression. Its unique binding affinity to the Hec1 protein alters microtubule dynamics, impacting spindle assembly and chromosome alignment. The compound's structural features enable specific interactions with key residues, modulating phosphorylation events and influencing cell cycle regulation. This specificity can lead to distinct effects on cellular proliferation and stability.

INH1

313553-47-8sc-295181
sc-295181A
10 mg
50 mg
$149.00
$638.00
(0)

INH1 acts as a potent hec1 inhibitor, exhibiting remarkable selectivity in disrupting the Hec1/Nek2 interaction. Its unique molecular architecture facilitates targeted binding to critical sites on the Hec1 protein, leading to altered conformational states that hinder microtubule attachment. This interference affects the kinetics of mitotic spindle formation, ultimately influencing chromosomal segregation. The compound's distinct physicochemical properties enhance its interaction dynamics, providing a nuanced approach to modulating cell cycle events.

GSK 923295

1088965-37-0sc-490136
5 mg
$290.00
(0)

GSK923295 is a potent Hec1 inhibitor that interferes with kinetochore-microtubule attachment. It disrupts Hec1 function, leading to mitotic defects and cell death.