| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1 | sc-221711 | 10 mg | $500.00 | |||
Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1, is a selective inhibitor that disrupts the Hec1/Nek2 signaling axis, crucial for mitotic progression. Its unique binding affinity to the Hec1 protein alters microtubule dynamics, impacting spindle assembly and chromosome alignment. The compound's structural features enable specific interactions with key residues, modulating phosphorylation events and influencing cell cycle regulation. This specificity can lead to distinct effects on cellular proliferation and stability. | ||||||
INH1 | 313553-47-8 | sc-295181 sc-295181A | 10 mg 50 mg | $149.00 $638.00 | ||
INH1 acts as a potent hec1 inhibitor, exhibiting remarkable selectivity in disrupting the Hec1/Nek2 interaction. Its unique molecular architecture facilitates targeted binding to critical sites on the Hec1 protein, leading to altered conformational states that hinder microtubule attachment. This interference affects the kinetics of mitotic spindle formation, ultimately influencing chromosomal segregation. The compound's distinct physicochemical properties enhance its interaction dynamics, providing a nuanced approach to modulating cell cycle events. | ||||||
GSK 923295 | 1088965-37-0 | sc-490136 | 5 mg | $290.00 | ||
GSK923295 is a potent Hec1 inhibitor that interferes with kinetochore-microtubule attachment. It disrupts Hec1 function, leading to mitotic defects and cell death. | ||||||