HE4 Inhibitors
Regarding the chemical class HE4 Inhibitors, these compounds represent a diverse group that can interact with cellular signaling pathways potentially linked to HE4. Their mechanisms of action include inhibition of Wnt signaling, alteration of protein folding and protein-protein interactions, disruption of cell adhesion and migration processes, and interference with various cancer-related signaling pathways such as MAPK/ERK, PI3K, and mTOR.
These compounds range from naturally occurring polyphenols like EGCG and quercetin to synthetic molecules like IWP-2 and Y-27632. Their action is centered around modulating cellular processes where HE4 is presumed to play a role. By targeting these pathways, these inhibitors aim to indirectly influence the activity of HE4, especially in contexts where it is implicated in abnormal cell behavior.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
Inhibits Wnt processing and secretion, potentially reducing HE4's involvement in Wnt signaling. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A polyphenol that might interfere with cell adhesion and migration processes, possibly affecting HE4's role in these processes. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Alters protein folding and can disrupt protein-protein interactions, possibly affecting HE4's function in cell signaling. | ||||||
NSC 668036 | 144678-63-7 | sc-507412 | 5 mg | $175.00 | ||
Wnt pathway inhibitor, might reduce HE4's involvement in this pathway. | ||||||
Salinomycin | 53003-10-4 | sc-253530 sc-253530C sc-253530A sc-253530B | 5 mg 10 mg 25 mg 100 mg | $159.00 $236.00 $398.00 $465.00 | 1 | |
Interferes with Wnt signaling and cancer stem cell survival, potentially influencing HE4 activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
ROCK inhibitor, might alter cell migration and adhesion, processes in which HE4 is involved. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MAPK/ERK inhibitor, could affect cell proliferation and survival pathways linked with HE4. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor, could influence pathways associated with HE4 in cancer cell survival and proliferation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
A flavonoid that may interfere with various signaling pathways, potentially impacting HE4's role. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
A compound that affects multiple signaling pathways and could modulate HE4's involvement in these pathways. | ||||||