HE4 Antibody (3F9): sc-293473
- HE4 Antibody (3F9) is a mouse monoclonal IgG2b κ HE4 antibody, cited in 6 publications, provided at 100 µg/ml
- raised against amino acids 31-124 representing full length HE4 of human origin
- recommended for detection of HE4 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HE4 Antibody (3F9). This work is in progress.
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HE4 Antibody (3F9) is a mouse monoclonal IgG2b kappa light chain antibody that detects HE4 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-HE4 antibody (3F9) is available as the non-conjugated format. HE4 protein, also known as whey acidic protein (WAP)-type four-disulfide core-2 or WFDC2, plays a significant role in reproductive biology, particularly in influencing sperm maturation, which is crucial for fertility. This small secretory protein is predominantly expressed in pulmonary epithelial cells and is also associated with certain ovarian cancers, making HE4 (3F9) antibody a valuable biomarker in oncology. Structurally, HE4 contains a WAP motif characterized by eight cysteines that form four disulfide bonds, which are essential for stability and function as a protease inhibitor. This motif not only contributes to structural integrity but also enhances proteolytic activity regulation in various physiological processes, underscoring HE4′s importance in both normal and pathological states.
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HE4 Antibody (3F9) References:
- The putative ovarian tumour marker gene HE4 (WFDC2), is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms. | Bingle, L., et al. 2002. Oncogene. 21: 2768-73. PMID: 11965550
- Mouse SWAM1 and SWAM2 are antibacterial proteins composed of a single whey acidic protein motif. | Hagiwara, K., et al. 2003. J Immunol. 170: 1973-9. PMID: 12574366
- The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma. | Hellström, I., et al. 2003. Cancer Res. 63: 3695-700. PMID: 12839961
- Ovarian cancer screening. | Urban, N., et al. 2003. Hematol Oncol Clin North Am. 17: 989-1005, ix. PMID: 12959188
- Transcriptional targeting in ovarian cancer cells using the human epididymis protein 4 promoter. | Berry, NB., et al. 2004. Gynecol Oncol. 92: 896-904. PMID: 14984958
- A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors. | Kirchhoff, C., et al. 1991. Biol Reprod. 45: 350-7. PMID: 1686187
- Serum HE4 Level as a Biomarker to Predict the Recurrence of Gynecologic Cancers. | Li, J., et al. 2017. Curr Drug Targets. 18: 1158-1164. PMID: 28382859
- Biomarkers and algorithms for diagnosis of ovarian cancer: CA125, HE4, RMI and ROMA, a review. | Dochez, V., et al. 2019. J Ovarian Res. 12: 28. PMID: 30917847
- HE4 Predicts Progressive Fibrosis and Cardiovascular Events in Patients With Dilated Cardiomyopathy. | Yamamoto, M., et al. 2021. J Am Heart Assoc. 10: e021069. PMID: 34320813
- Dapagliflozin Attenuates Contrast-induced Acute Kidney Injury by Regulating the HIF-1α/HE4/NF-κB Pathway. | Huang, X., et al. 2022. J Cardiovasc Pharmacol. 79: 904-913. PMID: 35383661
- HE4 and CA125 serum biomarker monitoring in women with epithelial ovarian cancer. | Samborski, A., et al. 2022. Tumour Biol. 44: 205-213. PMID: 36189508
- Recent Insight about HE4 Role in Ovarian Cancer Oncogenesis. | Anastasi, E., et al. 2023. Int J Mol Sci. 24: PMID: 37445657
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HE4 Antibody (3F9) | sc-293473 | 100 µg/ml | $316.00 |