Molecular structure of NSC 668036, CAS Number: 144678-63-7
NSC 668036 (CAS 144678-63-7)
Alternate Names:
N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-alanine, (1S)-1-carboxy-2-methylpropyl ester
CAS Number:
144678-63-7
Molecular Weight:
460.5
Molecular Formula:
C21H36N2O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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NSC 668036 (CAS 144678-63-7) References
- Identification of a specific inhibitor of the dishevelled PDZ domain. | Shan, J., et al. 2005. Biochemistry. 44: 15495-503. PMID: 16300398
- Optimizing Dvl PDZ domain inhibitor by exploring chemical space. | Shan, J. and Zheng, JJ. 2009. J Comput Aided Mol Des. 23: 37-47. PMID: 18780146
- Simulations of a specific inhibitor of the dishevelled PDZ domain. | Chen, X. and Deng, Y. 2009. J Mol Model. 15: 91-6. PMID: 18953581
- Identification of tripeptides recognized by the PDZ domain of Dishevelled. | Lee, HJ., et al. 2009. Bioorg Med Chem. 17: 1701-8. PMID: 19157887
- Human ASH-1 promotes neuroendocrine differentiation in androgen deprivation conditions and interferes with androgen responsiveness in prostate cancer cells. | Rapa, I., et al. 2013. Prostate. 73: 1241-9. PMID: 23657976
- Targeted inhibition of disheveled PDZ domain via NSC668036 depresses fibrotic process. | Wang, C., et al. 2015. Exp Cell Res. 331: 115-122. PMID: 25445788
- Axin is expressed in mitochondria and suppresses mitochondrial ATP synthesis in HeLa cells. | Shin, JH., et al. 2016. Exp Cell Res. 340: 12-21. PMID: 26704260
- Pharmacologic Inhibition of Porcupine, Disheveled, and β-Catenin in Wnt Signaling Pathway Ameliorates Diabetic Peripheral Neuropathy in Rats. | Resham, K. and Sharma, SS. 2019. J Pain. 20: 1338-1352. PMID: 31075529
- Pharmacological interventions targeting Wnt/β-catenin signaling pathway attenuate paclitaxel-induced peripheral neuropathy. | Resham, K. and Sharma, SS. 2019. Eur J Pharmacol. 864: 172714. PMID: 31586636
- Inhibition of Wnt-β-Catenin Signaling by ICRT14 Drug Depends of Post-Transcriptional Regulation by HOTAIR in Human Cervical Cancer HeLa Cells. | Trujano-Camacho, S., et al. 2021. Front Oncol. 11: 729228. PMID: 34778043
Inhibitor of:
APC, Axin, Dapper2, GPR177, HE4, LEF-1, SHKBP1, TCF-3, TMEM170B, WIF-1, WNT (Wingless Int-1), Wnt-1, Wnt-15, Wnt-3a, Wnt-5a, and Wnt-5b.Activator of:
EG245190, EG245263, EG245440, EG245651, and TMEM170B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NSC 668036, 5 mg | sc-507412 | 5 mg | $175.00 |