HCF1 Inhibitors
HCF1 inhibitors are compounds that can reduce the activity of the HCF1 protein, either directly or indirectly. These inhibitors often work by targeting specific cellular pathways or processes that are also involved in the function of HCF1.
Some inhibitors, like PD98059 and U0126, function by targeting kinases that are involved in the ERK pathway, which is key for cell proliferation and differentiation. By inhibiting this pathway, these compounds might reduce the activity of HCF1, which is also involved in these cellular processes. Other inhibitors, such as LY294002 and Wortmannin, target PI3K, a kinase that is crucial for cell proliferation and survival. These inhibitors might reduce HCF1 activity, given that HCF1 is also involved in these cellular processes.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a non-ATP competitive inhibitor of MEK, a kinase responsible for the activation of the ERK pathway. The ERK pathway is involved in various cellular processes including cell proliferation and differentiation, which HCF1 is also involved in. Therefore, inhibition of this pathway by PD98059 might lead to decreased activity of HCF1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of PI3K, a kinase involved in various cellular processes including cell proliferation and survival. By inhibiting PI3K, LY294002 might reduce the activity of HCF1, which is also involved in these processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of PI3K. By inhibiting PI3K, wortmannin might decrease the activity of HCF1, which is involved in cell proliferation and survival, processes that PI3K also influences. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK, a kinase involved in cell differentiation and apoptosis. The inhibition of p38 MAPK might lead to reduced activity of HCF1, which is involved in similar cellular processes. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, a kinase involved in various cellular processes including cell proliferation, differentiation, and apoptosis. By inhibiting JNK, SP600125 might reduce the activity of HCF1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an inhibitor of mTOR, a central regulator of cell growth and proliferation. By inhibiting mTOR, rapamycin can influence the cell cycle and other cellular processes, potentially leading to the decreased activity of HCF1. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a potent inhibitor of histone deacetylases (HDACs), which are involved in the regulation of gene expression. By inhibiting HDACs, Trichostatin A might reduce the activity of HCF1, which is involved in similar cellular processes. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
AG490 is an inhibitor of JAK2, a kinase involved in various cellular processes including cell proliferation and differentiation. By inhibiting JAK2, AG490 might decrease the activity of HCF1. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A is an immunosuppressant that inhibits calcineurin, a phosphatase involved in the activation of T cells. The inhibition of calcineurin might lead to reduced activity of HCF1, which is involved in similar cellular processes. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a nucleoside analogue of cytidine that inhibits DNA methyltransferase, leading to hypomethylation of DNA. This might decrease the activity of HCF1, which is involved in DNA replication and cell cycle progression. | ||||||