GST Inhibitors
SEE ALSO...
Items 1 to 10 of 18 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
This synthetic compound is a potent inhibitor of GST activity and has been studied for its chemoprotective effects against carcinogens. | ||||||
Captopril | 62571-86-2 | sc-200566 sc-200566A | 1 g 5 g | $49.00 $91.00 | 21 | |
Primarily known as an angiotensin-converting enzyme (ACE) inhibitor, captopril has been found to inhibit GST activity by binding to the enzyme and interfering with its catalytic function. | ||||||
Ethacrynic acid | 58-54-8 | sc-257424 sc-257424A | 1 g 5 g | $90.00 $300.00 | 5 | |
It is a non-specific GST inhibitor that covalently modifies the active site of GST enzymes, thereby inhibiting their activity. | ||||||
PGA2 (Prostaglandin A2) | 13345-50-1 | sc-201215 sc-201215A | 1 mg 10 mg | $214.00 $418.00 | 2 | |
This compound inhibits GST activity by binding covalently to the enzyme and disrupting its catalytic function. | ||||||
Hematin | 15489-90-4 | sc-207729 sc-207729A sc-207729D sc-207729C | 250 mg 1 g 100 g 10 g | $73.00 $80.00 $5728.00 $734.00 | 1 | |
It is an iron-containing compound that inhibits GST by binding to its active site and disrupting its catalytic function. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid present in various fruits and vegetables, it inhibits GST activity by directly binding to the enzyme and interfering with its catalytic function. | ||||||
Curcumin (Synthetic) | 458-37-7 | sc-294110 sc-294110A | 5 g 25 g | $52.00 $156.00 | 3 | |
Curcumin (Synthetic) exhibits remarkable behavior as a GST through its ability to engage in electrophilic attack, facilitated by its conjugated double bond system. This structure enhances its reactivity, allowing for efficient conjugation with glutathione. The compound's planar conformation promotes π-π stacking interactions, influencing binding affinity and selectivity. Additionally, its hydrophobic properties affect membrane permeability, altering its distribution and kinetics in biological environments. | ||||||
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $33.00 $136.00 $458.00 | 5 | |
Ebselen functions as a glutathione S-transferase (GST) by leveraging its unique selenium-containing structure, which allows for effective nucleophilic attack on electrophiles. Its ability to form stable selenol intermediates enhances reaction kinetics, facilitating rapid conjugation with glutathione. The compound's distinct redox properties enable it to participate in diverse biochemical pathways, while its amphiphilic nature influences solubility and interaction with cellular membranes, impacting its overall bioavailability. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Ellagic acid is a polyphenol found in fruits like berries and pomegranates. It has been investigated for its ability to inhibit GST activity. | ||||||
HELSS (Haloenol lactone suicide substrate, BEL, Bromoenol lactone) | 88070-98-8 | sc-201418 sc-201418A | 5 mg 25 mg | $163.00 $609.00 | 8 | |
HELSS, a bromoenol lactone, acts as a potent GST substrate through its electrophilic lactone moiety, which readily engages in nucleophilic attack by glutathione. This interaction leads to the formation of a stable thioether product, promoting efficient detoxification processes. The compound's unique structural features enhance its reactivity, allowing for selective targeting of specific GST isoforms. Additionally, its hydrophobic characteristics influence membrane permeability, affecting cellular uptake and distribution. | ||||||