Molecular structure of Ebselen, CAS Number: 60940-34-3
Ebselen (CAS 60940-34-3)
See product citations (5)
Alternate Names:
2-Phenyl-1,2-benzisoselenazol-3(2H)-one; Harmokisane
Application:
Ebselen is a cysteine modifier that inhibits 5-LO, 15-LO, Cox, NADPH, and NADPH oxidase
CAS Number:
60940-34-3
Purity:
≥98%
Molecular Weight:
274.18
Molecular Formula:
C13H9NOSe
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Ebselen is an organoselenium compound that displays anti-inflammatory and antioxidant properties. Ebselen is shown to modify cysteine residues and inhibit the 5-LO (5-lipoxygenase) and 15-LO enzymes in the absence of glutathione. Ebselen also inhibits protein kinase C, cyclooxygenases Cox-1 and Cox-2, NOS (Nitric oxide synthase), GST (glutathione S-transferase), IDO (Indoleamine-pyrrole 2,3-dioxygenase), NADPH (nicotinamide adenine dinucleotide phosphate oxidase), and NADPH oxidase. The oxidation of low density lipoproteins by free radicals is suppressed by the antioxidant action of Ebselen.
Ebselen (CAS 60940-34-3) References
- Ebselen: a thioredoxin reductase-dependent catalyst for alpha-tocopherol quinone reduction. | Fang, J., et al. 2005. Toxicol Appl Pharmacol. 207: 103-9. PMID: 15979675
- Inhibitory effect of ebselen on cerebral acetylcholinesterase activity in vitro: kinetics and reversibility of inhibition. | Martini, F., et al. 2015. Curr Pharm Des. 21: 920-4. PMID: 25312723
- Repurposing Auranofin, Ebselen, and PX-12 as Antimicrobial Agents Targeting the Thioredoxin System. | May, HC., et al. 2018. Front Microbiol. 9: 336. PMID: 29556223
- The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation. | Capper, MJ., et al. 2018. Nat Commun. 9: 1693. PMID: 29703933
- Targeting the Mycobacterium tuberculosis transpeptidase LdtMt2 with cysteine-reactive inhibitors including ebselen. | de Munnik, M., et al. 2019. Chem Commun (Camb). 55: 10214-10217. PMID: 31380528
- Ebselen attenuates tobramycin-induced ototoxicity in mice. | Gu, R., et al. 2021. J Cyst Fibros. 20: 271-277. PMID: 32147183
- Ebselen ameliorates renal ischemia-reperfusion injury via enhancing autophagy in rats. | Wu, Y., et al. 2022. Mol Cell Biochem. 477: 1873-1885. PMID: 35338455
- Antibacterial Activity of Ebselen. | Maślanka, M. and Mucha, A. 2023. Int J Mol Sci. 24: PMID: 36675123
- Molecular actions of ebselen--an antiinflammatory antioxidant. | Schewe, T. 1995. Gen Pharmacol. 26: 1153-69. PMID: 7590103
- Ebselen: a glutathione peroxidase mimic. | Sies, H. 1994. Methods Enzymol. 234: 476-82. PMID: 7808321
- Effects of ebselen and probucol on oxidative modifications of lipid and protein of low density lipoprotein induced by free radicals. | Noguchi, N., et al. 1994. Biochim Biophys Acta. 1213: 176-82. PMID: 8025128
- Strong inhibition of mammalian lipoxygenases by the antiinflammatory seleno-organic compound ebselen in the absence of glutathione. | Schewe, C., et al. 1994. Biochem Pharmacol. 48: 65-74. PMID: 8043032
- Interaction of ebselen with glutathione S-transferase and papain in vitro. | Nikawa, T., et al. 1994. Biochem Pharmacol. 47: 1007-12. PMID: 8147899
- Ebselen, a selenoorganic compound as glutathione peroxidase mimic. | Sies, H. 1993. Free Radic Biol Med. 14: 313-23. PMID: 8458589
- Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite. | Sies, H. and Masumoto, H. 1997. Adv Pharmacol. 38: 229-46. PMID: 8895811
Inhibitor of:
α-defensin 2, α-defensin 6, β-Arrestin-2, β-defensin 130, β-defensin 131, 12-LO, 15-LO, 2810408P10Rik, 5-LO, 9130014G24Rik, A630033E08Rik, AATM, AKR1B10, AKR1C21, ALOXE3, apoL7b, AsnRS, ASTE1, AU017455, AZ2, CABC1, CCL (C-C motif chemokine ligand), ChM-I, CHMP7, CNOX, Cox, Cox-2, Cyp4f14, DECR1, DPP3, EG665927, FAM105B, GGCT, gp91-phox, gp91phox, GPx-1, GPx-2, Grx2, GSH-2, GST, GSTA2, GSTK1, GSTP1, Hep A, Iba1, IDO, IMP-3, IMPA1, IMPA3, KRTAP12-2, LCE1E, LCE2B, Lipid A, Ly6G6c, LYZL2, MCP-1, Mcsp, MOX-1, MsrA, MsrB3, MTERFD3, NAIP2, NIBP, NOS, NOXA1, NOXO1, NOXRED1, NSP3, Nucleoredoxin, OASL2, p22-phox, p40-phox, p47-phox, Pex7p, PHYHD1, PKC, Prdx6-rs2, PRG-3, PRX II, PRX1, PRX2, PSTK, Rad27, RADIL, RDH11, Ros, SBP-2, SDR39U1, SELB, selenocysteine lyase, Selenoprotein I, Selenoprotein K, Selenoprotein M marker, Selenoprotein S, Selenoprotein V, Selenoprotein W, SEP15, SEPHS1, SEPHS2, Ser/Thr Protein Kinase, SMNDC1, SPLUNC2, Streptolysin, Svs7, TATDN2, Tau, TMC8, TRPC4AP, Trx-2, TrxR1, TrxR2, TXNDC10, TXNDC13, TXNDC14, TXNL6, UGRP2, ZIP3, ZNF191, ZNF202, ZNF256, ZNF407, ZNF552, ZNF555, ZNF682, ZNF701, and ZNF708.Activator of:
9430025M13Rik, AKR1B7, GGCT, GPx-4, GPx-6, GPx-8, KSP37, Miner2, Mox1, PDIR, SELENBP2, selenocysteine lyase, Selenoprotein M, Selenoprotein N, Selenoprotein O, Selenoprotein R, Sptrx-1, Trx, and TrxR3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ebselen, 1 mg | sc-200740B | 1 mg | $33.00 | |||
Ebselen, 25 mg | sc-200740 | 25 mg | $136.00 | |||
Ebselen, 100 mg | sc-200740A | 100 mg | $458.00 |