Molecular structure of Curcumin (Synthetic), CAS Number: 94875-80-6
Curcumin (Synthetic) (CAS 458-37-7)
See product citations (3)
Application:
Curcumin (Synthetic) is reported to suppress COX-1, COX-2, NF-κB and other inflammatory mediators
CAS Number:
458-37-7
Purity:
≥95%
Molecular Weight:
368.38
Molecular Formula:
C21H20O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Curcumin is a compound found in turmeric, a spice derived from the roots of the plant Curcuma longa. It is responsible for the distinctive yellow color of turmeric and has a variety of properties that make it interesting for study. Curcumin interacts with multiple molecular targets involved in inflammation, oxidative processes, and cell signaling. This interaction contributes to its ability to modulate these biological processes. Due to its polyphenolic structure, curcumin is also explored for its role in binding to proteins and potentially interfering with certain cellular functions. Its solubility in water is limited, which influences its behavior in biological systems.
Curcumin (Synthetic) (CAS 458-37-7) References
- Dietary curcuminoids prevent high-fat diet-induced lipid accumulation in rat liver and epididymal adipose tissue. | Asai, A. and Miyazawa, T. 2001. J Nutr. 131: 2932-5. PMID: 11694621
- Antioxidant and anti-inflammatory properties of curcumin. | Menon, VP. and Sudheer, AR. 2007. Adv Exp Med Biol. 595: 105-25. PMID: 17569207
- Curcumin has bright prospects for the treatment of inflammatory bowel disease. | Hanai, H. and Sugimoto, K. 2009. Curr Pharm Des. 15: 2087-94. PMID: 19519446
- Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease. | Epstein, J., et al. 2010. Br J Nutr. 103: 824-32. PMID: 19878610
- New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases. | Shehzad, A., et al. 2011. Eur J Nutr. 50: 151-61. PMID: 21442412
- A review on antibacterial, antiviral, and antifungal activity of curcumin. | Moghadamtousi, SZ., et al. 2014. Biomed Res Int. 2014: 186864. PMID: 24877064
- Impact of curcumin on toll-like receptors. | Boozari, M., et al. 2019. J Cell Physiol. 234: 12471-12482. PMID: 30623441
- A Review of Curcumin and Its Derivatives as Anticancer Agents. | Tomeh, MA., et al. 2019. Int J Mol Sci. 20: PMID: 30818786
- Curcumin and Heme Oxygenase: Neuroprotection and Beyond. | Mhillaj, E., et al. 2019. Int J Mol Sci. 20: PMID: 31100781
- Curcumin ameliorates oxidative stress-induced intestinal barrier injury and mitochondrial damage by promoting Parkin dependent mitophagy through AMPK-TFEB signal pathway. | Cao, S., et al. 2020. Free Radic Biol Med. 147: 8-22. PMID: 31816386
- Antitumor Activity of Curcumin in Glioblastoma. | Walker, BC. and Mittal, S. 2020. Int J Mol Sci. 21: PMID: 33322413
- The role of curcumin in aging and senescence: Molecular mechanisms. | Zia, A., et al. 2021. Biomed Pharmacother. 134: 111119. PMID: 33360051
- The Functional Roles of Curcumin on Astrocytes in Neurodegenerative Diseases. | Mohammadi, A., et al. 2022. Neuroimmunomodulation. 29: 4-14. PMID: 34496365
Inhibitor of:
5-LO, Cox, Cox-2, CREB Binding Protein (CBP), GST, IKK, JNK, NF kappa B, NOS2, NQO1, p300, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Curcumin (Synthetic), 5 g | sc-294110 | 5 g | $51.00 | |||
Curcumin (Synthetic), 25 g | sc-294110A | 25 g | $153.00 |