GRASP55 Activators
GRASP55 Activators refer to a set of chemical compounds that indirectly enhance the functional activity of GRASP55, a protein involved in the stacking and linking of Golgi cisternae. The activation of GRASP55 is facilitated through various cellular signaling pathways that are influenced by these compounds. Compounds such as Forskolin, Rolipram, Sp-8-Br-cAMPS, and 8-CPT-cAMP elevate the intracellular levels of cAMP, leading to the activation of PKA. This kinase is known to phosphorylate a range of substrates, including those associated with GRASP55, thereby potentially enhancing GRASP55's role in maintaining the structural integrity of the Golgi apparatus. Similarly, compounds that modulate the intracellular calcium concentration, like IonomIt appears there was an error in the previous response. Here is the correct completion of the information:
GRASP55 Activators encompass a collection of chemical compounds that enhance the functional activity of GRASP55 through indirect pathways. These compounds influence various cellular processes and signaling cascades, ultimately leading to the activation of GRASP55. For example, Forskolin, by activating adenylate cyclase, increases cAMP levels, which in turn activates PKA. PKA then phosphorylates proteins that may interact with GRASP55, thus enhancing its role in maintaining Golgi structure. Rolipram and Sp-8-Br-cAMPS also elevate cAMP levels but through different mechanisms, with Rolipram inhibiting PDE4 to prevent cAMP degradation, and Sp-8-Br-cAMPS being a direct PKA activator. Through these actions, they facilitate GRASP55's function in the Golgi apparatus.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, which increases levels of cAMP in cells. Elevated cAMP activates PKA (protein kinase A), which can phosphorylate various proteins, including molecular chaperones that associate with GRASP55, resulting in enhanced functional activity of GRASP55 in the mediation of Golgi stack formation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which degrades cAMP. By inhibiting PDE4, rolipram increases intracellular cAMP levels, subsequently activating PKA. This may enhance the phosphorylation state of proteins that interact with GRASP55, leading to an increase in GRASP55-mediated Golgi apparatus stacking. | ||||||
8-Bromo-cGMP | 51116-01-9 | sc-200316 sc-200316A | 10 mg 50 mg | $104.00 $354.00 | 7 | |
Sp-8-Br-cAMPS is a cell-permeable cAMP analog that activates PKA. PKA activation can lead to the phosphorylation of proteins associated with GRASP55, which may enhance the functional activity of GRASP55 in Golgi structure maintenance. | ||||||
8-CPT-cAMP | 93882-12-3 | sc-201569 sc-201569A | 20 mg 100 mg | $87.00 $316.00 | 19 | |
8-CPT-cAMP is a cell-permeable cAMP analog that serves as an activator of PKA. By stimulating PKA, it can indirectly enhance the phosphorylation and function of GRASP55 in the assembly and maintenance of the Golgi apparatus. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Calcium is a secondary messenger that can influence various signaling pathways, including those that may phosphorylate proteins interacting with GRASP55, potentially enhancing GRASP55 activity in Golgi stacking. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, which can cause ER stress and may lead to the activation of signaling pathways that enhance the functional activity of GRASP55 in response to misfolded protein accumulation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that leads to the accumulation of ubiquitinated proteins, potentially increasing the demand for GRASP55 function in the formation of Golgi stacks to process misfolded proteins. | ||||||
NOC-18 | 146724-94-9 | sc-202247 sc-202247A sc-202247B sc-202247C | 10 mg 50 mg 100 mg 500 mg | $51.00 $184.00 $305.00 $1122.00 | 18 | |
NOC-18 releases nitric oxide, which can function as a signaling molecule that activates guanylate cyclase, leading to cGMP production. cGMP can activate PKG, which might phosphorylate substrates that interact with GRASP55, enhancing its function. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore similar to ionomycin, which also increases intracellular calcium levels, potentially enhancing GRASP55 activity by influencing calcium-dependent signaling pathways. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol is a compound that induces heat shock response, which can lead to the upregulation of molecular chaperones that may interact with GRASP55, thereby enhancing its functional activity in Golgi organization. | ||||||