Molecular structure of NOC-18, CAS Number: 146724-94-9
NOC-18 (CAS 146724-94-9)
See product citations (18)
Alternate Names:
Diethylenetriamine/nitric oxide adduct; DETA NONOate
Application:
NOC-18 is a diazeniumdiolate slow-releasing NO donor
CAS Number:
146724-94-9
Purity:
≥95%
Molecular Weight:
163.18
Molecular Formula:
C4H13N5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NOC-18 is a diazeniumdiolate (NONOate) small molecule NO donor designed to release NO at a slower rate than other available diazeniumdiolates, boasting a half-life for NO release of 20 hr. This slow release of NO allows use of NOC-18 in experiments investigating the effects of prolonged, constant NO delivery to cells and tissues. NOC-18 was demonstrated to prevent low density lipoprotein peroxidation by Cu2+ modulated by the NO released, and the particularly slow rate of NO release generated by NOC-18 was shown to protect against LDL peroxidation much more effectively than the quick-releasing NOC-9 (sc-202250, half-life of 2.7 min) by providing a continuous flux of NO to the system.
NOC-18 (CAS 146724-94-9) References
- Effect of age on rat aortic responses to acetylcholine and nitric oxide donor (NOC-18). | Kano, Y., et al. 1999. Res Commun Mol Pathol Pharmacol. 105: 173-6. PMID: 10850380
- Effect of age on rat aortic responses to acetylcholine and nitric oxide donor (NOC-18). | Kano, Y., et al. 2000. Res Commun Mol Pathol Pharmacol. 107: 331-4. PMID: 11484887
- Proinflammatory cytokines suppress the expression level of protease-activated receptor-2 through the induction of iNOS in rat colon. | Horie, A., et al. 2009. J Vet Med Sci. 71: 1609-15. PMID: 20046028
- Nitric oxide blocks cellular heme insertion into a broad range of heme proteins. | Waheed, SM., et al. 2010. Free Radic Biol Med. 48: 1548-58. PMID: 20211245
- Neuroprotective effects of nitric oxide donor NOC-18 against brain ischemia-induced mitochondrial damages: role of PKG and PKC. | Arandarcikaite, O., et al. 2015. Neurosci Lett. 586: 65-70. PMID: 25219376
- Fibrinogen Chains Intrinsic to the Brain. | Golanov, EV., et al. 2019. Front Neurosci. 13: 541. PMID: 31191233
- Nitric Oxide Donor NOC-18-Induced Changes of Mitochondrial Phosphoproteome in Rat Cardiac Ischemia Model. | Umbrasas, D., et al. 2019. Medicina (Kaunas). 55: PMID: 31554309
- Nitric oxide down-regulates voltage-gated Na+ channel in cardiomyocytes possibly through S-nitrosylation-mediated signaling. | Wang, P., et al. 2021. Sci Rep. 11: 11273. PMID: 34050231
- Nitric oxide (NO) donor molecules: effect of NO release rate on vascular smooth muscle cell proliferation in vitro. | Mooradian, DL., et al. 1995. J Cardiovasc Pharmacol. 25: 674-8. PMID: 7596138
- NOC, a nitric-oxide-releasing compound, induces dose dependent apoptosis in macrophages. | Shimaoka, M., et al. 1995. Biochem Biophys Res Commun. 209: 519-26. PMID: 7733920
- Intracerebroventricular administration of a nitric oxide-releasing compound, NOC-18, produces thermal hyperalgesia in rats. | Shibuta, S., et al. 1995. Neurosci Lett. 187: 103-6. PMID: 7783955
- Inhibition of Cu2+-induced LDL oxidation by nitric oxide: a study using donors with different half-time of NO release. | Seccia, M., et al. 1996. Biochem Biophys Res Commun. 220: 306-9. PMID: 8645301
- 'NONOates' (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms. | Keefer, LK., et al. 1996. Methods Enzymol. 268: 281-93. PMID: 8782594
- A new nitric oxide donor, NOC-18, exhibits a nociceptive effect in the rat formalin model. | Shibuta, S., et al. 1996. J Neurol Sci. 141: 1-5. PMID: 8880684
- Intrathecal administration of a new nitric oxide donor, NOC-18, produces acute thermal hyperalgesia in the rat. | Inoue, T., et al. 1997. J Neurol Sci. 153: 1-7. PMID: 9455970
Inhibitor of:
MMADHC, and Olr1462.Activator of:
0610008F07Rik, 1700020A23Rik, 1700027N10Rik, 6430548M08Rik, ARFRP1, ARHGAP12, BC002199, BC016201, Dexras2, E. coli, FHR-5, FLRT2, GAP1m, gp91phox, GRASP55, HNK-1ST, MAAI, Olfr301, OR1B1, PB1, PDEF, PRX V, Ran BP-6, SNX33, STAG3, Syndecan-3, Trak1, UTP18, WDR76, and ZFP820.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NOC-18, 10 mg | sc-202247 | 10 mg | $51.00 | |||
NOC-18, 50 mg | sc-202247A | 50 mg | $184.00 | |||
NOC-18, 100 mg | sc-202247B | 100 mg | $305.00 | |||
NOC-18, 500 mg | sc-202247C | 500 mg | $1122.00 |