Molecular structure of 8-Bromo-cGMP, CAS Number: 51116-01-9
8-Bromo-cGMP (CAS 51116-01-9)
See product citations (7)
Alternate Names:
8-BR-cGMP sodium salt;8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt
Application:
8-Bromo-cGMP is a cell-permeable cGMP analog resistance to hydrolysis than cGMP
CAS Number:
51116-01-9
Purity:
≥96%
Molecular Weight:
446.08
Molecular Formula:
C10H10BrN5O7P•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
8-Bromo-cGMP is a cell-permeable cGMP analog with greater resistance to hydrolysis by phosphodiesterases than cGMP. The compound may act to preferentially activate cGKIalpha/beta (cGMP-dependent protein kinase). In human platelets, 8-Bromo-cGMP has been found to inhibit thrombin stimulated arachidonic acid release. 8-Bromo-cGMP is known to slow or inhibit intracellular calcium oscillations of tracheal smooth muscle cells in response to acetylcholine.
8-Bromo-cGMP (CAS 51116-01-9) References
- Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats. | Tegeder, I., et al. 2002. Neurosci Lett. 332: 146-50. PMID: 12384231
- Effect of acute in vivo sildenafil citrate and in vitro 8-bromo-cGMP treatments on semen parameters and sperm function. | du Plessis, SS., et al. 2004. Fertil Steril. 81: 1026-33. PMID: 15066459
- Relaxation of hormonally stimulated smooth muscular tissues by the 8-bromo derivative of cyclic GMP. | Schultz, KD., et al. 1979. Naunyn Schmiedebergs Arch Pharmacol. 306: 1-9. PMID: 218117
- Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. | Garg, UC. and Hassid, A. 1989. J Clin Invest. 83: 1774-7. PMID: 2540223
- Inhibition of rat mesangial cell mitogenesis by nitric oxide-generating vasodilators. | Garg, UC. and Hassid, A. 1989. Am J Physiol. 257: F60-6. PMID: 2546445
- Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets. | Sane, DC., et al. 1989. Biochem Biophys Res Commun. 165: 708-14. PMID: 2557018
- Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase. | Francis, SH., et al. 1988. Mol Pharmacol. 34: 506-17. PMID: 2845250
- Effects of 8-bromo-cGMP on Ca2+ levels in vascular smooth muscle cells: possible regulation of Ca2+-ATPase by cGMP-dependent protein kinase. | Rashatwar, SS., et al. 1987. Proc Natl Acad Sci U S A. 84: 5685-9. PMID: 3039502
- Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity. | Meyer, RB. and Miller, JP. 1974. Life Sci. 14: 1019-40. PMID: 4362776
- 8-bromo-cGMP reduces the myofilament response to Ca2+ in intact cardiac myocytes. | Shah, AM., et al. 1994. Circ Res. 74: 970-8. PMID: 8156644
- Specific effects of n-3 fatty acids and 8-bromo-cGMP on the cyclic nucleotide phosphodiesterase activity in neonatal rat cardiac myocytes. | Picq, M., et al. 1996. J Mol Cell Cardiol. 28: 2151-61. PMID: 8930810
- Nitric oxide inhibits ACh-induced intracellular calcium oscillations in porcine tracheal smooth muscle. | Prakash, YS., et al. 1997. Am J Physiol. 272: L588-96. PMID: 9142929
- Effects of 8-bromo-cyclic GMP on membrane potential of single swine tracheal smooth muscle cells. | Choi, J. and Farley, JM. 1998. J Pharmacol Exp Ther. 285: 588-94. PMID: 9580602
Inhibitor of:
C20orf152, LRRC64, Olfr437, Olfr691, Olfr692, Olfr693, Olfr694, Olfr781, Olfr782, Olfr784, Olfr888, Olfr993, Olfr994, Olfr995, Olfr996, and Olfr998.Activator of:
1700007E06Rik, 1700052N19Rik, acrogranin, Adducin β, Bride of Sevenless, C14orf54, C20orf135, CAPS1, CCDC155, CdcA7, cGKI, COL4A1, CRIP3, cyclin G1, Dexras1, Dlx-6, EBV EBNA-3A, EF-CAB4A, EG624219, Emi2, EphA7, EXDL2, FAM22D, FBXO44, FSCB, GBP2, GPR123, GPR161, GRASP55, HIGD2A, HOP-1, LOC339809, LT-β, MBNL2, nephrocystin-4, NPR-B, NUDT12, Olfr462, Olfr463, Olfr464, Olfr94, Olfr943, Olfr944, Olfr967, PCBP4, PKDCC, PTN, Relaxin Receptor 2, ROD, ROM1, Shigatoxin 2, SMYD1, SNX30, SP140L, STK31, TIGD7, TSGA10, TTC7B, URG4, V1rg10, vanin-2, WDR21B, and ZP4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-Bromo-cGMP, 10 mg | sc-200316 | 10 mg | $102.00 | |||
8-Bromo-cGMP, 50 mg | sc-200316A | 50 mg | $347.00 |