Grap Activators
Chemicals that indirectly lead to the functional activation of the GRAP protein do so by modulating various signaling pathways and cellular processes that GRAP is known to be involved in. Lithium Chloride, for instance, inhibits glycogen synthase kinase 3 (GSK-3), a negative regulator of the Wnt signaling pathway. This inhibition can lead to the stabilization and accumulation of β-catenin, a component that can drive the transcription of various genes, potentially including GRAP, thereby increasing its expression and activity. Forskolin, Isoproterenol, and IBMX all act to increase the levels of cyclic AMP (cAMP) within cells, which activates protein kinase A (PKA). The activation of PKA can lead to a range of downstream effects including the phosphorylation of proteins that could enhance the activation state or expression of GRAP.
Similarly, ionomycin, by increasing intracellular calcium levels, can activate calcium-dependent signaling pathways, which might influence the activity of GRAP. TPA is a well-known activator of protein kinase C (PKC), which plays a significant role in intracellular signaling and can phosphorylate proteins within the Ras-MAPK pathway where GRAP functions. Dibutyryl-cAMP, as a cAMP analog, serves a similar function to Forskolin by activating PKA and potentially affecting GRAP activity. Anisomycin acts as a stress-activated protein kinase activator, which can lead to the activation of the MAPK pathway, possibly resulting in the activation of GRAP through its involvement in this pathway. Sodium Orthovanadate serves as a phosphatase inhibitor, which can lead to increased phosphorylation levels within the cell, affecting various signaling pathways including those that GRAP is part of. Okadaic Acid, by inhibiting protein phosphatases, can also result in enhanced phosphorylation signaling, potentially affecting GRAP's activation state. Piceatannol and LY294002 modulate kinase activity, thereby influencing signaling pathways and possibly leading to changes in the activation state of GRAP, as these kinases are part of the complex cellular signaling networks that GRAP is involved in.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK-3, leading to increased activation of the Wnt signaling pathway, which can enhance the expression of genes including GRAP. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylyl cyclase, increasing cAMP levels which can lead to activation of PKA and potentially enhance the expression or activity of GRAP. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
β-adrenergic receptor agonist, increasing cAMP and activating PKA, which can lead to upregulation or activation of GRAP as part of the signaling cascade. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Non-selective inhibitor of phosphodiesterases, increases cAMP levels, which can enhance the signaling pathways involving PKA and potentially GRAP activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Increases intracellular calcium levels, which can activate signaling pathways that lead to the activation of GRAP. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Direct activator of PKC, which can phosphorylate and activate proteins in the Ras-MAPK pathway, including GRAP. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
cAMP analog that activates PKA, potentially leading to enhanced activation or expression of GRAP. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Activates MAPK pathways by acting as a JNK activator, which can subsequently lead to GRAP activation as part of the signaling cascade. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Inhibits protein tyrosine phosphatases, which can enhance tyrosine phosphorylation signaling pathways involving GRAP activation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation and potential activation of signaling pathways involving GRAP. | ||||||