Date published: 2025-11-22

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GR Activators

GR Activators are a broad class of chemical compounds that interact with the Glucocorticoid Receptor (GR) to elicit a biological response. These compounds can either be endogenous, such as the naturally occurring hormone cortisol, or exogenous, like synthetic molecules specifically designed to modulate the activity of the receptor. GR activators generally work by binding to the ligand-binding domain of the receptor, inducing a conformational change that facilitates its translocation to the nucleus. In the nucleus, the activated receptor forms complexes with specific DNA sequences known as glucocorticoid response elements (GREs). This interaction ultimately leads to the transcriptional regulation of a myriad of genes involved in various physiological processes like metabolism, immune response, and stress regulation. By modulating gene expression, GR activators can have a profound impact on cellular function and organismal physiology. The chemical structures of GR activators can vary widely, ranging from small organic molecules to more complex synthetic derivatives. Despite the diversity in chemical makeup, most GR activators share common features that facilitate effective binding to the receptor, such as a steroid-like core structure. The selectivity and affinity for the receptor are determined by the presence of functional groups and the overall three-dimensional arrangement of the molecule. Various assays and computational methods are often employed to study the binding kinetics and functional consequences of GR activators. Understanding these properties is crucial for elucidating the cellular mechanisms underlying their effects and for furthering our grasp of glucocorticoid receptor biology.

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Items 1 to 10 of 21 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Dexamethasone Sodium Phosphate

2392-39-4sc-204715
sc-204715A
100 mg
500 mg
$54.00
$155.00
7
(1)

Dexamethasone Sodium Phosphate (CAS 2392-39-4) is a water-soluble salt form of dexamethasone, a synthetic glucocorticoid. It acts as an activator of the glucocorticoid receptor (GR), influencing various cellular processes such as transcription regulation and protein synthesis. This activation leads to anti-inflammatory and immunosuppressive effects at the cellular level.

Corticosterone

50-22-6sc-300391
sc-300391A
100 mg
500 mg
$57.00
$108.00
2
(2)

Corticosterone (CAS 50-22-6) is a naturally occurring glucocorticoid steroid hormone that serves as an activator of the glucocorticoid receptor (GR). When bound to GR, corticosterone can modulate a variety of cellular processes, including transcriptional regulation and protein synthesis. This leads to effects like anti-inflammation and immunosuppression at the cellular level.

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$76.00
$82.00
$367.00
36
(1)

Dexamethasone is a synthetic glucocorticoid that is known to activate the glucocorticoid receptor. It may increase the expression of the receptor by promoting gene transcription and protein stabilization.

Glucocorticoid Receptor Modulator, CpdA

14593-25-0sc-221677
25 mg
$150.00
2
(1)

Glucocorticoid Receptor Modulator, CpdA (CAS 14593-25-0) is a selective modulator of the glucocorticoid receptor (GR). It acts as an activator of GR, affecting transcriptional regulation and protein synthesis within cells. Its selective modulation leads to cellular effects like anti-inflammatory and immunosuppressive actions without fully mimicking natural glucocorticoids.

Betamethasone

378-44-9sc-204647
sc-204647A
100 mg
500 mg
$160.00
$555.00
(1)

Betamethasone (CAS 378-44-9) is a synthetic glucocorticoid that serves as an activator of the glucocorticoid receptor (GR). Upon binding to GR, it influences cellular activities such as transcriptional regulation and protein synthesis. Its activation of GR results in anti-inflammatory and immunosuppressive effects at the cellular level.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

Curcumin is a polyphenol compound found in turmeric. It may enhance the expression of the glucocorticoid receptor by modulating intracellular signaling pathways that control receptor synthesis.

Fluticasone propionate

80474-14-2sc-218517
10 mg
$180.00
(0)

Fluticasone Propionate (CAS 80474-14-2) is a synthetic glucocorticoid that acts as an activator of the glucocorticoid receptor (GR). Binding to GR allows it to regulate transcription and protein synthesis in cells. This activation leads to anti-inflammatory and immunosuppressive cellular responses, making it effective in modulating various biological processes.

Desonide

638-94-8sc-211275
10 mg
$171.00
(1)

Desonide (CAS 638-94-8) is a synthetic glucocorticoid that functions as an activator of the glucocorticoid receptor (GR). Upon binding to GR, it affects cellular processes such as transcriptional regulation and protein synthesis. This activation leads to anti-inflammatory and immunosuppressive responses at the cellular level.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

Resveratrol is a phytoalexin found in red grapes and wine. It may induce glucocorticoid receptor expression by influencing epigenetic modifications and thus enabling more effective receptor transcription.

Flumethasone

2135-17-3sc-211520
250 mg
$255.00
1
(0)

Flumethasone (CAS 2135-17-3) is a synthetic glucocorticoid that acts as an activator of the glucocorticoid receptor (GR). When bound to GR, it modulates cellular activities like transcription regulation and protein synthesis. This results in anti-inflammatory and immunosuppressive effects at the cellular level.