GR/NR3C1/Glucocorticoid Receptor Antibody (G-5): sc-393232

GR Antibody (G-5) is a mouse monoclonal IgG2b kappa light chain antibody that detects GR (glucocorticoid receptor) of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). GR (G-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GR (glucocorticoid receptor) is a critical transcription factor that plays a vital role in mediating the physiological effects of glucocorticoids, which are steroid hormones involved in numerous biological processes such as metabolism, immune response, and stress regulation. GR (glucocorticoid receptor) is predominantly located in the cytoplasm, where GR exists in an inactive form bound to heat shock proteins, particularly HSP90. Upon binding to glucocorticoids, GR (glucocorticoid receptor) translocates to the nucleus, where GR regulates gene expression by either inducing or repressing target genes. This translocation allows GR (glucocorticoid receptor) to interact with specific DNA sequences and recruit co-regulators that modulate transcription. GR (glucocorticoid receptor)′s ability to influence gene expression is essential for maintaining homeostasis and responding to environmental changes, making GR a significant target for therapeutic interventions in conditions such as inflammation, autoimmune diseases, and cancer.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GR/NR3C1/Glucocorticoid Receptor Antibody (G-5) has 98 citations in a variety of scientific publications.

Primary antibodies like Anti-GR/NR3C1/Glucocorticoid Receptor Antibody (G-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GR/NR3C1/Glucocorticoid Receptor Antibody (G-5) Specifications

Alternate Product Name: glucocorticoid receptor

Product Clone Name: G-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 121-420

Epitope Target: GR

Epitope Species: human

Product Reactivity/Detection: GR α and GR β

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 98 citations in various scientific publications

Available Conjugates/Forms for GR/NR3C1/Glucocorticoid Receptor Antibody (G-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent

The preferred GR/NR3C1/Glucocorticoid Receptor antibody is GR/NR3C1/Glucocorticoid Receptor Antibody (3D5): sc-56851.