Molecular structure of Flumethasone, CAS Number: 2135-17-3
Flumethasone (CAS 2135-17-3)
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Alternate Names:
(6α,11β,16α)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 6α,9α-Difluoro-16α-methylprednisolone; 6α-Fluorodexamethasone; 6α-Fluorodexamethazone; Anaprime; Aniprime; Aniprome; Cortexillar; Flucort; Flucorticin; Flumetasone; Flumethason; Fluvet; Methagon; NSC 5402; NSC 54702; RS 2177; U 10974; Vecort
Application:
Flumethasone is A glucocorticoid. An anti-inflammatory.
CAS Number:
2135-17-3
Purity:
≥99%
Molecular Weight:
410.45
Molecular Formula:
C22H28F2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Flumethasone functions as a potent anti-inflammatory agent. It exerts its mechanism of action by binding to cytoplasmic glucocorticoid receptors, leading to the formation of a receptor-ligand complex. This complex then translocates into the nucleus, where it modulates gene expression by binding to specific DNA sequences. Flumethasone ultimately suppresses the transcription of pro-inflammatory genes, thereby reducing the production of inflammatory mediators such as cytokines and chemokines. It inhibits the activity of phospholipase A2, leading to decreased production of prostaglandins and leukotrienes. Flumethasone also has immunosuppressive effects by inhibiting the function of immune cells such as T-lymphocytes and macrophages.
Flumethasone (CAS 2135-17-3) References
- Determination of flumethasone in calf urine and serum by liquid chromatography-tandem mass spectrometry. | Brambilla, G., et al. 2001. J Chromatogr B Biomed Sci Appl. 755: 265-78. PMID: 11393713
- [The effectiveness of cholecalciferol and flumethasone for the prevention of hypocalcemic parturient paresis in dairy cows]. | Karatzias, H. 1992. Dtsch Tierarztl Wochenschr. 99: 326-7. PMID: 1330480
- Effect of steroidal and non-steroidal anti-inflammatory drugs in combination with long-acting oxytetracycline on non-specific immunity of calves suffering from enzootic bronchopneumonia. | Bednarek, D., et al. 2003. Vet Microbiol. 96: 53-67. PMID: 14516708
- Development of QuEChERS-based extraction and liquid chromatography-tandem mass spectrometry method for quantifying flumethasone residues in beef muscle. | Park, KH., et al. 2012. Meat Sci. 92: 749-53. PMID: 22819726
- Simultaneous detection of flumethasone, dl-methylephedrine, and 2-hydroxy-4,6-dimethylpyrimidine in porcine muscle and pasteurized cow milk using liquid chromatography coupled with triple-quadrupole mass spectrometry. | Zhang, D., et al. 2016. J Chromatogr B Analyt Technol Biomed Life Sci. 1012-1013: 8-16. PMID: 26797492
- Stimulation of androgen and oestrogen concentrations in plasma of cows after administration of a synthetic glucocorticoid (flumethasone) at the end of gestation. | Möstl, E., et al. 1985. J Endocrinol. 105: 121-6. PMID: 2985724
- Flumethasone enhances the efficacy of chemotherapeutic drugs in lung cancer by inhibiting Nrf2 signaling pathway. | Zhou, Y., et al. 2020. Cancer Lett. 474: 94-105. PMID: 31954771
- Effect of day gestation on inductions of lambing with flumethasone. | Rommereim, DN. and Slyter, AL. 1981. J Anim Sci. 53: 564-6. PMID: 7319950
- [Bouble-blind unilateral comparison of difluocortolone valerate and flumethasone pivalate ointments]. | Ruiz, EM., et al. 1976. Z Hautkr. 51 Suppl 1: 51-5. PMID: 795190
- Immunoaffinity chromatography combined with gas chromatography-negative ion chemical ionisation mass spectrometry for the confirmation of flumethasone abuse in the equine. | Stanley, SM., et al. 1993. J Chromatogr. 614: 77-86. PMID: 8496289
- Dexamethasone and flumethasone residues in milk of intramuscularly dosed cows. | Reding, J., et al. 1997. J Vet Pharmacol Ther. 20: 198-203. PMID: 9185085
- Efficacy of the combination sodium ceftiofur-flumethasone in the treatment of experimental Pasteurella haemolytica bronchopneumonia in calves. | Sustronck, B., et al. 1997. Zentralbl Veterinarmed A. 44: 179-87. PMID: 9197206
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GR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Flumethasone, 250 mg | sc-211520 | 250 mg | $260.00 |