Molecular structure of Glucocorticoid Receptor Modulator, CpdA, CAS Number: 14593-25-0
Glucocorticoid Receptor Modulator, CpdA (CAS 14593-25-0)
See product citations (2)
Alternate Names:
2-((4-Acetoxyphenyl)-2-chloro-N-methyl)ethylammonium chloride
Application:
Glucocorticoid Receptor Modulator, CpdA is a cell-permeable aziridine precursor
CAS Number:
14593-25-0
Purity:
≥97%
Molecular Weight:
264.15
Molecular Formula:
C11H14ClNO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Glucocorticoid receptor modulator, CpdA, is a cell-permeable aziridine precursor that acts as a non-steroidal, GR (glucocorticoid receptor)-activating ligand with a binding affinity that is 4-fold higher than that of dexamethasone (sc-29059). Glucocorticoid Receptor Modulator, CpdA, induces GR nuclear translocation and selectively activates GR-mediated transrepression of the NF-kappaB-dependent production of pro-inflammatory cytokines. Unlike DEX, Glucocorticoid receptor modulator, CpdA exhibits no effect on GRE- (glucocorticoid response element) driven gene expression.
Glucocorticoid Receptor Modulator, CpdA (CAS 14593-25-0) References
- Inhibition of cytochrome P450c11 by biogenic amines and an aziridine precursor, 2-(4-acetoxyphenyl)-2-chloro-N-methyl-ethylammonium chloride. | Louw, A., et al. 2000. Endocr Res. 26: 729-36. PMID: 11196449
- Selective transrepression versus transactivation mechanisms by glucocorticoid receptor modulators in stress and immune systems. | De Bosscher, K., et al. 2008. Eur J Pharmacol. 583: 290-302. PMID: 18289525
- Compound A, a dissociated glucocorticoid receptor modulator, reduces dengue virus-induced cytokine secretion and dengue virus production. | Suttitheptumrong, A., et al. 2013. Biochem Biophys Res Commun. 436: 283-8. PMID: 23743190
- Selective glucocorticoid receptor modulation: New directions with non-steroidal scaffolds. | Sundahl, N., et al. 2015. Pharmacol Ther. 152: 28-41. PMID: 25958032
- Inhibition of dengue virus production and cytokine/chemokine expression by ribavirin and compound A. | Rattanaburee, T., et al. 2015. Antiviral Res. 124: 83-92. PMID: 26542647
- Mechanism for the stabilization in vivo of the aziridine precursor --(4-acetoxyphenyl)-2-chloro-N-methyl-ethylammonium chloride by serum proteins. | Louw, A., et al. 1997. Biochem Pharmacol. 53: 189-97. PMID: 9037251
Inhibitor of:
ACSL1, DUB1A, DUB2, DUB2A, and Epac.Activator of:
GR, and MAML3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Glucocorticoid Receptor Modulator, CpdA, 25 mg | sc-221677 | 25 mg | $150.00 |