Date published: 2026-2-23

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GR Activators

GR Activators are a broad class of chemical compounds that interact with the Glucocorticoid Receptor (GR) to elicit a biological response. These compounds can either be endogenous, such as the naturally occurring hormone cortisol, or exogenous, like synthetic molecules specifically designed to modulate the activity of the receptor. GR activators generally work by binding to the ligand-binding domain of the receptor, inducing a conformational change that facilitates its translocation to the nucleus. In the nucleus, the activated receptor forms complexes with specific DNA sequences known as glucocorticoid response elements (GREs). This interaction ultimately leads to the transcriptional regulation of a myriad of genes involved in various physiological processes like metabolism, immune response, and stress regulation. By modulating gene expression, GR activators can have a profound impact on cellular function and organismal physiology. The chemical structures of GR activators can vary widely, ranging from small organic molecules to more complex synthetic derivatives. Despite the diversity in chemical makeup, most GR activators share common features that facilitate effective binding to the receptor, such as a steroid-like core structure. The selectivity and affinity for the receptor are determined by the presence of functional groups and the overall three-dimensional arrangement of the molecule. Various assays and computational methods are often employed to study the binding kinetics and functional consequences of GR activators. Understanding these properties is crucial for elucidating the cellular mechanisms underlying their effects and for furthering our grasp of glucocorticoid receptor biology.

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Items 11 to 20 of 21 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Desonide-13C3

sc-218160
1 mg
$360.00
(0)

Desonide-13C3 is an isotopically labeled variant of desonide, a synthetic glucocorticoid. It acts as an activator of the glucocorticoid receptor (GR). Upon binding, it influences cellular processes like transcriptional regulation and protein synthesis. Its activation of GR results in anti-inflammatory and immunosuppressive responses at the cellular level.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$110.00
$250.00
$936.00
$50.00
33
(2)

Quercetin is a flavonoid compound that may upregulate glucocorticoid receptor expression by activating certain signaling pathways that lead to enhanced gene transcription.

Flumethasone pivalate

2002-29-1sc-235147
100 mg
$183.00
(0)

Flumethasone Pivalate (CAS 2002-29-1) is a synthetic glucocorticoid that functions as an activator of the glucocorticoid receptor (GR). Upon binding to GR, it modulates cellular activities such as transcriptional regulation and protein synthesis. This activation leads to cellular effects like anti-inflammation and immunosuppression.

D,L-Sulforaphane

4478-93-7sc-207495A
sc-207495B
sc-207495C
sc-207495
sc-207495E
sc-207495D
5 mg
10 mg
25 mg
1 g
10 g
250 mg
$153.00
$292.00
$489.00
$1325.00
$8465.00
$933.00
22
(1)

D,L-Sulforaphane is a compound found in cruciferous vegetables. It may influence the expression of the glucocorticoid receptor through its role in cellular stress response mechanisms.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Retinoic acid is a metabolite of vitamin A. It may promote the expression of the glucocorticoid receptor by enhancing gene transcription through the activation of retinoic acid receptors.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$45.00
$164.00
$200.00
$402.00
$575.00
$981.00
$2031.00
46
(1)

Genistein is an isoflavone found in soy. It may induce glucocorticoid receptor expression by modulating gene transcription and protein stabilization processes.

Caffeine

58-08-2sc-202514
sc-202514A
sc-202514B
sc-202514C
sc-202514D
50 g
100 g
250 g
1 kg
5 kg
$33.00
$67.00
$97.00
$192.00
$775.00
13
(1)

Caffeine is an alkaloid stimulant. It may induce glucocorticoid receptor expression by influencing cAMP signaling pathways, leading to the activation of transcription factors responsible for receptor synthesis.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$43.00
$73.00
$126.00
$243.00
$530.00
$1259.00
11
(1)

(-)-Epigallocatechin Gallate is a catechin found in green tea. It may upregulate the expression of the glucocorticoid receptor by modulating cellular oxidative stress pathways.

Indole-3-carbinol

700-06-1sc-202662
sc-202662A
sc-202662B
sc-202662C
sc-202662D
1 g
5 g
100 g
250 g
1 kg
$39.00
$61.00
$146.00
$312.00
$1032.00
5
(1)

Indole-3-carbinol is a compound found in cruciferous vegetables. It may increase the expression of the glucocorticoid receptor through its influence on gene transcription and protein stabilization.

Luteolin

491-70-3sc-203119
sc-203119A
sc-203119B
sc-203119C
sc-203119D
5 mg
50 mg
500 mg
5 g
500 g
$27.00
$51.00
$101.00
$153.00
$1925.00
40
(1)

Luteolin is a flavone compound that may upregulate glucocorticoid receptor expression by activating signaling pathways that lead to enhanced gene transcription.