GPR177 Inhibitors
GPR177 inhibitors represent a class of chemicals designed to modulate the activity of GPR177, a key regulator involved in Wnt signaling pathways. Among these inhibitors, IWP-2 and IWP-L6 stand out as indirect inhibitors that disrupt Wnt production and secretion. By preventing the palmitoylation and release of Wnt ligands mediated by GPR177, these inhibitors influence downstream Wnt signaling pathways, leading to altered cellular responses in various biological contexts. Wnt-C59 and XAV-939, another set of indirect inhibitors, act by targeting different aspects of Wnt signaling. Wnt-C59 blocks the production of active Wnt ligands, while XAV-939 stabilizes Axin by inhibiting tankyrase, indirectly impacting GPR177-mediated Wnt signaling. These inhibitors provide valuable tools to dissect the complex regulatory roles of GPR177 in cellular processes influenced by Wnt pathways.
The direct inhibition of GPR177 is not yet well-established, but compounds like LGK-974 and KY02111 indirectly modulate GPR177 by interfering with Wnt ligand acylation and secretion. CCT036477, Salinomycin, PRI-724, NSC668036, and WIKI4 represent additional indirect inhibitors targeting Wnt signaling pathways to influence GPR177-mediated cellular responses. In summary, the chemical class of GPR177 inhibitors comprises a diverse array of compounds that either directly or indirectly modulate GPR177, impacting Wnt signaling pathways. These inhibitors offer valuable tools to unravel the intricate roles of GPR177 in cellular processes influenced by Wnt signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
IWP-2 is a small-molecule inhibitor of Wnt production. It indirectly inhibits GPR177 by disrupting the secretion of Wnt ligands. Wnt ligands are palmitoylated by GPR177, and their inhibition by IWP-2 prevents GPR177 from palmitoylating and releasing Wnt, consequently affecting downstream Wnt signaling pathways that involve GPR177. | ||||||
Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $210.00 $320.00 $1250.00 | 1 | |
Wnt-C59 is a small-molecule inhibitor of Wnt signaling. It indirectly inhibits GPR177 by blocking the production of active Wnt ligands. This inhibition prevents GPR177 from palmitoylating and releasing Wnt, influencing downstream signaling cascades. The indirect modulation by Wnt-C59 impacts cellular processes associated with GPR177-mediated Wnt signaling, contributing to altered cellular responses. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
XAV-939 is a tankyrase inhibitor that indirectly influences GPR177 by stabilizing Axin, a key component in the β-catenin destruction complex. The inhibition of tankyrase by XAV-939 leads to the stabilization of Axin, enhancing the degradation of β-catenin. Consequently, GPR177's involvement in Wnt signaling is indirectly impacted, influencing cellular responses associated with GPR177-mediated Wnt pathways. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $132.00 | 19 | |
IWR-1 is a Wnt signaling pathway inhibitor. It indirectly inhibits GPR177 by interfering with the secretion and maturation of Wnt ligands. The inhibition of Wnt ligand production by IWR-1 prevents GPR177-mediated palmitoylation and release of Wnt, affecting downstream Wnt signaling pathways. This indirect modulation by IWR-1 influences cellular processes associated with GPR177-mediated Wnt signaling. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $352.00 $1270.00 | 2 | |
LGK-974 is a small-molecule inhibitor of Porcupine, an enzyme involved in Wnt ligand acylation. By inhibiting Porcupine, LGK-974 indirectly influences GPR177 by disrupting the production and maturation of Wnt ligands. This disruption prevents GPR177 from palmitoylating and releasing Wnt, affecting downstream Wnt signaling pathways and modulating cellular responses associated with GPR177-mediated Wnt signaling. | ||||||
KY02111 | 1118807-13-8 | sc-397043 sc-397043A | 5 mg 25 mg | $79.00 $336.00 | ||
KY02111 is a small-molecule Wnt inhibitor that indirectly modulates GPR177. By inhibiting the secretion and maturation of Wnt ligands, KY02111 disrupts GPR177-mediated palmitoylation and release of Wnt. This indirect inhibition influences downstream Wnt signaling pathways, leading to altered cellular responses associated with GPR177-mediated Wnt signaling in various biological contexts. | ||||||
CCT036477 | 305372-78-5 | sc-391631A sc-391631 | 5 mg 25 mg | $107.00 $428.00 | 1 | |
CCT036477 is a tankyrase inhibitor that indirectly influences GPR177 by stabilizing Axin and enhancing the degradation of β-catenin. The inhibition of tankyrase by CCT036477 disrupts the GPR177-mediated Wnt signaling pathway. The indirect modulation by CCT036477 impacts cellular processes associated with GPR177-mediated Wnt signaling, offering insights into potential therapeutic interventions in diseases related to aberrant Wnt signaling. | ||||||
Salinomycin | 53003-10-4 | sc-253530 sc-253530C sc-253530A sc-253530B | 5 mg 10 mg 25 mg 100 mg | $159.00 $236.00 $398.00 $465.00 | 1 | |
Salinomycin is an antibiotic that indirectly inhibits GPR177 by targeting Wnt signaling. It interferes with Wnt production and maturation, preventing GPR177-mediated palmitoylation and release of Wnt. This indirect modulation by Salinomycin influences downstream Wnt signaling pathways, impacting cellular responses associated with GPR177-mediated Wnt signaling in various biological contexts. | ||||||
PRI-724 | 1422253-38-0 | sc-507535 | 25 mg | $255.00 | ||
PRI-724 is a small-molecule inhibitor of the Wnt/β-catenin pathway. It indirectly inhibits GPR177 by interfering with Wnt signaling, preventing GPR177-mediated palmitoylation and release of Wnt ligands. The indirect modulation by PRI-724 affects downstream Wnt signaling pathways, influencing cellular processes associated with GPR177-mediated Wnt signaling in diverse biological contexts. | ||||||
NSC 668036 | 144678-63-7 | sc-507412 | 5 mg | $175.00 | ||
NSC668036 is a small-molecule inhibitor that indirectly modulates GPR177 by targeting the Wnt signaling pathway. By interfering with Wnt ligand production and maturation, NSC668036 prevents GPR177-mediated palmitoylation and release of Wnt. This indirect modulation affects downstream Wnt signaling pathways, influencing cellular responses associated with GPR177-mediated Wnt signaling in various biological contexts. | ||||||