CCT036477 (CAS 305372-78-5)

CCT036477 is a chemical compound recognized for its role as an inhibitor of the Wnt signaling pathway, a critical regulator of cellular communication involved in numerous biological processes, including cell proliferation, migration, and polarity. Specifically, CCT036477 targets the pathway by inhibiting the transcriptional activity mediated by β-catenin, a central player in the Wnt signaling cascade. The mechanism of action of CCT036477 is particularly interesting because it disrupts the interaction between β-catenin and its co-factors in the nucleus, thereby preventing the transcription of Wnt target genes. This inhibition is significant as it allows researchers to study the effects of Wnt signaling suppression in various cellular contexts, without affecting the upstream components of the pathway. In scientific research, CCT036477 has been utilized to explore the role of Wnt signaling in controlling cell fate decisions and in maintaining the balance between stem cell renewal and differentiation. The ability of CCT036477 to selectively inhibit Wnt/β-catenin mediated transcription provides a valuable tool for dissecting the complex network of signals that govern cellular behavior and for understanding how aberrations in this pathway can influence cellular function.