Molecular structure of LGK 974, CAS Number: 1243244-14-5
LGK 974 (CAS 1243244-14-5)
See product citations (2)
Alternate Names:
PORCN Inhibitor IV
Application:
LGK 974 is a potent and specific small molecule Porcupine (PORCN) inhibitor
CAS Number:
1243244-14-5
Molecular Weight:
396.44
Molecular Formula:
C23H20N6O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
LGK 974 is a chemical compound primarily utilized in oncological research due to its inhibitory action on the Wnt signaling pathway, which is known to play a critical role in the regulation of cell proliferation and differentiation. This compound is of particular interest in the study of cancers where the Wnt pathway is aberrantly activated, as it provides a model for understanding the molecular dynamics of tumor growth and progression. It serves as a useful tool in dissecting the complex biology of Wnt-related proteins and their interactions, contributing to the field of molecular oncology. Moreover, LGK 974 is employed in stem cell research, where modulation of the Wnt pathway can influence stem cell fate decisions, offering insights into tissue regeneration and repair mechanisms.
LGK 974 (CAS 1243244-14-5) References
- LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974. | Jang, J., et al. 2017. Sci Rep. 7: 41612. PMID: 28128299
- Molecular genetics and targeted therapy of WNT-related human diseases (Review). | Katoh, M. and Katoh, M. 2017. Int J Mol Med. 40: 587-606. PMID: 28731148
- Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency. | Kawarazaki, W., et al. 2020. J Clin Invest. 130: 4152-4166. PMID: 32597829
- WLS-Wnt signaling promotes neuroendocrine prostate cancer. | Bland, T., et al. 2021. iScience. 24: 101970. PMID: 33437943
- Porcupine inhibitors: Novel and emerging anti-cancer therapeutics targeting the Wnt signaling pathway. | Shah, K., et al. 2021. Pharmacol Res. 167: 105532. PMID: 33677106
- Porcupine inhibitor LGK‑974 inhibits Wnt/β‑catenin signaling and modifies tumor‑associated macrophages resulting in inhibition of the malignant behaviors of non‑small cell lung cancer cells. | Tang, Y., et al. 2021. Mol Med Rep. 24: PMID: 34080032
- Recent updates on Wnt signaling modulators: a patent review (2014-2020). | Goswami, VG. and Patel, BD. 2021. Expert Opin Ther Pat. 31: 1009-1043. PMID: 34128760
- FSH stimulated bovine granulosa cell steroidogenesis involves both canonical and noncanonical WNT signaling. | Ashry, M., et al. 2022. Domest Anim Endocrinol. 78: 106678. PMID: 34607220
- The porcupine inhibitor WNT974 provokes ectodermal lineage differentiation of human embryonic stem cells. | Kalantary-Charvadeh, A., et al. 2022. Cell Biochem Funct. 40: 359-368. PMID: 35445405
- Mechanisms and inhibition of Porcupine-mediated Wnt acylation. | Liu, Y., et al. 2022. Nature. 607: 816-822. PMID: 35831507
- Blockade of Wnt Secretion Attenuates Myocardial Ischemia-Reperfusion Injury by Modulating the Inflammatory Response. | Meyer, IS., et al. 2022. Int J Mol Sci. 23: PMID: 36293109
- The chromatin remodeler CHD6 promotes colorectal cancer development by regulating TMEM65-mediated mitochondrial dynamics via EGF and Wnt signaling. | Zhang, B., et al. 2022. Cell Discov. 8: 130. PMID: 36473865
- Immature natural killer cells promote progression of triple-negative breast cancer. | Thacker, G., et al. 2023. Sci Transl Med. 15: eabl4414. PMID: 36888695
- Targeting Wnt-ß-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling. | Nayakanti, SR., et al. 2023. Circ Res.. PMID: 37042252
Inhibitor of:
β-catenin, 9430069J07Rik, AMCase, APC, APCDD1, ARMC7, Bcl-9, brachyury 2, C1orf67, C2CD4A, CAGE, Cdk8, Chibby 3, Cypt3, DAAM1, Dapper3, DIXDC1, Dkk-1, Dkk-4, EAP1, EG245190, EG435927, EG436188, F-Spondin, FOXD4, frizzled-8, GBX2, GPR177, HNF-3β, HOS, HoxA13, HoxC11, HoxD10, HR, ICAT, IQCK, ITF-1, Kremen-2, LEF-1, LGR5, LGR6, LMBR1L, LOC257407, LOC388963, LOC666145, LOC729556, LRP5, LRP6, LZTFL1, MAB-5, MESDC2, mPRβ, Notum, PCDH11X, PDH-E1α, POP-1, PORCN, Prickle4, Pygopus 1, R-Spondin, R-Spondin2, R-Spondin3, R-Spondin4, Rhox2a, Rhox2b, SAV1, Scratch1, SEMA6D, SFRS16, SHISA3, SHKBP1, SIP1, Soggy-1, Spondin (SPON), TCF-1, TCF-19, TMEM161B, TMEM170B, TMEM46, TMEM88, TMEM9, U11, UCH-L3, Vangl1, WDPCP, WDR27, WFIKKN, WIF-1, WISP-3, WNT (Wingless Int-1), Wnt-1, Wnt-10b, Wnt-14, Wnt-15, Wnt-2, Wnt-3, Wnt-3a, Wnt-5b, Wnt-6, Wnt-7a, WTIP, WTX, Zic3, ZNF705D, and ZNRF3.Activator of:
CELSR1, Conductin, frizzled-1, frizzled-2, frizzled-6, Kremen-1, LGR4, MAB21L2, MACS1, MIA2, MLLT11, OR52N2, Pcdhgb8, Prickle1, Pygopus 2, RNF43, Rslcan-5, Rslcan-6, Rslcan-7, TCL-6, TMEM170B, UHRF1BP1, and Wnt-10a.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LGK 974, 5 mg | sc-489380 | 5 mg | $352.00 | |||
LGK 974, 50 mg | sc-489380A | 50 mg | $1270.00 |