Molecular structure of PRI-724, CAS Number: 1422253-38-0
PRI-724 (CAS 1422253-38-0)
CAS Number:
1422253-38-0
Molecular Weight:
658.6
Molecular Formula:
C33H35N6O7P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
PRI-724 (CAS 1422253-38-0) References
- Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/β-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Single-Center, Open-Label, Dose Escalation Phase 1 Trial. | Kimura, K., et al. 2017. EBioMedicine. 23: 79-87. PMID: 28844410
- Anti-tumor Activity of the Small Molecule Inhibitor PRI-724 Against β-Catenin-activated Hepatocellular Carcinoma. | Gabata, R., et al. 2020. Anticancer Res. 40: 5211-5219. PMID: 32878809
- Targeting of Deregulated Wnt/β-Catenin Signaling by PRI-724 and LGK974 Inhibitors in Germ Cell Tumor Cell Lines. | Schmidtova, S., et al. 2021. Int J Mol Sci. 22: PMID: 33923996
- Safety, tolerability, and anti-fibrotic efficacy of the CBP/β-catenin inhibitor PRI-724 in patients with hepatitis C and B virus-induced liver cirrhosis: An investigator-initiated, open-label, non-randomised, multicentre, phase 1/2a study. | Kimura, K., et al. 2022. EBioMedicine. 80: 104069. PMID: 35605429
- Inhibition of CBP/β-catenin signaling ameliorated fibrosis in cholestatic liver disease. | Kimura, M., et al. 2022. Hepatol Commun. 6: 2732-2747. PMID: 35855613
- E7386 is not a Specific CBP/β-Catenin Antagonist. | Higuchi, Y., et al. 2024. Curr Mol Pharmacol. 17: e290523217409. PMID: 37254542
- Machine learning on large scale perturbation screens for SARS-CoV-2 host factors identifies β-catenin/CBP inhibitor PRI-724 as a potent antiviral. | Kelch, MA., et al. 2023. Front Microbiol. 14: 1193320. PMID: 37342561
- Combinations of PRI-724 Wnt/β-Catenin Pathway Inhibitor with Vismodegib, Erlotinib, or HS-173 Synergistically Inhibit Head and Neck Squamous Cancer Cells. | Kleszcz, R., et al. 2023. Int J Mol Sci. 24: PMID: 37445628
- Molecular insights of a CBP/β-catenin-signaling inhibitor on nonalcoholic steatohepatitis-induced liver fibrosis and disorder. | Yamaji, K., et al. 2023. Biomed Pharmacother. 166: 115379. PMID: 37647690
- PRI-724 and IWP-O1 Wnt Signaling Pathway Inhibitors Modulate the Expression of Glycolytic Enzymes in Tongue Cancer Cell Lines. | Kleszcz, R., et al. 2023. Curr Issues Mol Biol. 45: 9579-9592. PMID: 38132445
Inhibitor of:
β-catenin, APC, APCDD1, Bcl-9, brachyury 2, Chibby 3, Dapper1, Dapper2, Dkk-4, Dmp1, EG245190, GPR177, HOS, ICAT, LEF-1, LGR5, LIN-44, LOC666145, LRP4, LRP5, LRP6, Nucleoredoxin, Pygopus 1, R-Spondin, SHISA3, TBL1XR1, TCF-3, TLE1, TLE4, TMEM170B, TNIK, V1RG12, WIF-1, WISP-1, WNT (Wingless Int-1), Wnt-1, Wnt-14, Wnt-14b, Wnt-2, Wnt-3, Wnt-3a, Wnt-6, Wnt-7a, ZNF883, and ZNRF3.Activator of:
FRP-3, nudel, RNF43, Sox-7, and TMEM170B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PRI-724, 25 mg | sc-507535 | 25 mg | $255.00 |