Molecular structure of Wnt-C59, CAS Number: 1243243-89-1
Wnt-C59 (CAS 1243243-89-1)
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Alternate Names:
4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]-benzeneacetamide
Application:
Wnt-C59 is a porcupine homolog – Drosophila (PORCN) inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase
CAS Number:
1243243-89-1
Molecular Weight:
379.45
Molecular Formula:
C25H21N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Wnt-C59 is a small molecule inhibitor that functions by targeting the Wnt signaling pathway. It acts by binding to the acyltransferase Porcupine, which is responsible for the palmitoylation of Wnt proteins. This binding prevents the secretion of Wnt proteins, thereby inhibiting the activation of the Wnt signaling pathway. By disrupting this pathway, Wnt-C59 effectively modulates cellular processes such as proliferation, differentiation, and migration. At the molecular level, Wnt-C59 exerts its action by interfering with the post-translational modification of Wnt proteins, ultimately leading to the downregulation of Wnt signaling.
Wnt-C59 (CAS 1243243-89-1) References
- Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. | Proffitt, KD., et al. 2013. Cancer Res. 73: 502-7. PMID: 23188502
- Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment. | Cheng, Y., et al. 2015. Oncotarget. 6: 14428-39. PMID: 25980501
- WNT-C59, a Small-Molecule WNT Inhibitor, Efficiently Induces Anterior Cortex That Includes Cortical Motor Neurons From Human Pluripotent Stem Cells. | Motono, M., et al. 2016. Stem Cells Transl Med. 5: 552-60. PMID: 26941358
- Canonical and non-canonical WNT signaling in cancer stem cells and their niches: Cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review). | Katoh, M. 2017. Int J Oncol. 51: 1357-1369. PMID: 29048660
- Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation (Review). | Katoh, M. 2018. Int J Mol Med. 42: 713-725. PMID: 29786110
- LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/β-catenin pathway and predicts poor survival of glioma patients. | Zhang, J., et al. 2018. J Exp Clin Cancer Res. 37: 225. PMID: 30208924
- Lactobacillus reuteri maintains intestinal epithelial regeneration and repairs damaged intestinal mucosa. | Wu, H., et al. 2020. Gut Microbes. 11: 997-1014. PMID: 32138622
- Wnt-C59 Attenuates Pressure Overload-Induced Cardiac Hypertrophy via Interruption of Wnt Pathway. | Zhao, Z., et al. 2020. Med Sci Monit. 26: e923025. PMID: 32279067
- Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis. | Wu, CL., et al. 2021. Nat Commun. 12: 362. PMID: 33441552
- Porcupine inhibitors: Novel and emerging anti-cancer therapeutics targeting the Wnt signaling pathway. | Shah, K., et al. 2021. Pharmacol Res. 167: 105532. PMID: 33677106
- Inhibiting Wnt/beta-catenin in CTNNB1-mutated endometrial cancer. | Moroney, MR., et al. 2021. Mol Carcinog. 60: 511-523. PMID: 34038589
- Wnt-C59 inhibits proinflammatory cytokine expression by reducing the interaction between β-catenin and NF-κB in LPS-stimulated epithelial and macrophage cells. | Jang, J., et al. 2021. Korean J Physiol Pharmacol. 25: 307-319. PMID: 34193644
- Wnt-Signaling Inhibitor Wnt-C59 Suppresses the Cytokine Upregulation in Multiple Organs of Lipopolysaccharide-Induced Endotoxemic Mice via Reducing the Interaction between β-Catenin and NF-κB. | Jang, J., et al. 2021. Int J Mol Sci. 22: PMID: 34200709
- Morphological neurite changes induced by porcupine inhibition are rescued by Wnt ligands. | Godoy, JA., et al. 2021. Cell Commun Signal. 19: 87. PMID: 34399774
Inhibitor of:
β-catenin, 2610208M17Rik, 4930434E21Rik, ALS2CR4, ArgBP2a, ARMC7, Barhl2, BNIP-2, BOC, C11orf60, C16orf54, C17orf89, C1orf187, C1orf80, C2orf15, C9orf57, CASPR2, CBWD5, CELSR1, CELSR2, claudin-6, copine 2, Cripto-3, D53, DAPLE, DERP6, DIP2B, DRG2, EG245190, EG435927, Esgp, Fmi2, FOXD3, FOXF1, FOXL1, GLIPR1L3, GLIS1, GLTSCR1, Gm12, Gm765, GPR177, Hairless, Hepatocyte Specific Antigen, HOS, HoxB2, HR, IQCK, ITF-1, LCORL, LEF-1, LGR5, LHX1, LHX3, LIN-39, LIN-44, LOC100041061, LOC100041425, LOC100041426, LOC100041430, LOC348751, LOC727873, LOC728720, LOC728861, LRP5L, LRRC36, LRTM1, Lunatic Fringe, MAB-5, MESDC2, MGAT3, MIZIP, MXL-1, Myosin 18B, Nanog, Neuroglycan C, neuromedin C, Nlk, Notum, OLFML3, Olr270, OR7A17, OSR2, Pals2, PCDH11X, PCDHGA3, Pitx3, POP-1, PORCN, Prickle1, PROX2, PRR16, PSAPL1, PSG, Psg17, Pygopus 1, Reg 1α, RFX4, Rho GDI 2, Ripply1, SEMA5A, Semaphorin, SHISA3, SHOX2, Sidekick-2, SLC35F5, Slit3, Spi-C, SPINK4, SREB3, Stannin, Tβ-4, TBX1, TLE1, TLE4, TMEM26, TTC30B, UNCX, V1RG12, VAX2, VRTN, WDR62, Wnt, Wnt-1, Wnt-14, Wnt-14b, Wnt-6, WTIP, ZBTB42, ZBTB8, ZNF175, ZNF439, ZNF883, ZNRF3, and ZSWIM2.Activator of:
AIDA, ANKRD40, ASB-1, BBS10, C16orf79, Conductin, DIXDC1, Dkk-2, Dvl-3, INTU, IRX6, LHX2, LIN-31, neuropilin, Pbx 4, RG9MTD3, RUNDC1, Scrib, Vangl1, Wnt-11, Wnt-14b, and Wnt-5b.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Wnt-C59, 5 mg | sc-475634 | 5 mg | $210.00 | |||
Wnt-C59, 10 mg | sc-475634A | 10 mg | $320.00 | |||
Wnt-C59, 50 mg | sc-475634B | 50 mg | $1250.00 |