Gm765 Activators
MyoD family inhibitor domain containing 2 activators encompass a diverse range of chemical compounds that influence different cellular pathways, ultimately converging on the enhancement of the protein's role in myogenic differentiation and muscle cell lineage commitment. Forskolin, by raising intracellular cAMP levels, activates PKA, which can phosphorylate and regulate proteins that interact with MyoD family inhibitor domain containing 2. Similarly, PMA-induced PKC activation and ionomycin-mediated CaMK activation can lead to the phosphorylation of proteins that enhance MyoD family inhibitor domain containing 2 activity. Lithium chloride and BIO, through their inhibitory action on GSK-3, may stabilize proteins and signaling pathways that support MyoD family inhibitor domain containing 2 function. The inhibition of TGF-β signaling by SB 431542 could shift the balance towards signaling pathways that favor MyoD family inhibitor domain containing 2 activity.
Further, AICAR's activation of AMPK, TrichostatinA's HDAC inhibition, and Y-27632's ROCK inhibition each provide a biochemical milieu that can augment the activity of MyoD family inhibitor domain containing 2 in muscle differentiation. PD 0332991's targeted action on CDK4/6 modulates cell cycle progression, influencing the cellular context in which MyoD family inhibitor domain containing 2 operates. LY294002's inhibition of the PI3K/AKT pathway and rapamycin's interference with mTOR signaling both lead to changes in downstream protein synthesis and degradation, which could support the functional enhancement of MyoD family inhibitor domain containing 2, promoting its role in the development and differentiation of muscle cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can then phosphorylate substrates that may interact with MyoD family inhibitor domain containing 2, enhancing its function in muscle cell differentiation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in numerous signaling pathways. PKC activation can lead to phosphorylation of factors that interact with MyoD family inhibitor domain containing 2, thereby enhancing its activity in myogenesis. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calmodulin-dependent kinase (CaMK). Activated CaMK can then phosphorylate proteins that may promote the activity of MyoD family inhibitor domain containing 2 in muscle differentiation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase 3 (GSK-3). Inhibition of GSK-3 can stabilize proteins and enhance pathways that support the function of MyoD family inhibitor domain containing 2 in muscle cell lineage commitment. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB 431542 is a selective inhibitor of the TGF-β type I receptor ALK5, which leads to the inhibition of Smad2/3 signaling. This inhibition can enhance the activity of alternative signaling pathways that may positively regulate MyoD family inhibitor domain containing 2 function in myogenic differentiation. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $57.00 $184.00 $867.00 | 10 | |
BIO is a specific GSK-3 inhibitor that can lead to the stabilization and activation of factors that enhance the function of MyoD family inhibitor domain containing 2, promoting myoblast differentiation. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMP-activated protein kinase (AMPK), which can then modulate substrate proteins that facilitate MyoD family inhibitor domain containing 2's role in muscle cell differentiation and growth. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is an inhibitor of histone deacetylases (HDACs). Inhibition of HDACs can result in a more relaxed chromatin structure at promoters of genes involved in myogenesis, potentially enhancing the activity of MyoD family inhibitor domain containing 2. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor which can lead to actin cytoskeleton rearrangement and may influence signaling pathways that enhance the activity of MyoD family inhibitor domain containing 2 in muscle cell function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which can lead to alterations in AKT signaling pathways. This modulation can enhance signaling cascades that upregulate the function of MyoD family inhibitor domain containing 2 in muscle differentiation. | ||||||