Gm606 Activators
Geminin Coiled-Coil Domain Containing (GMNC) activators are a class of chemicals that are postulated to enhance the functional activity of GMNC through various signaling mechanisms. Forskolin, by stimulating adenylate cyclase, raises intracellular cAMP levels, which in turn activates PKA. The activated PKA can phosphorylate a range of proteins, potentially including GMNC. This phosphorylation can regulate GMNC's activity in the context of its role in cell cycle regulation. IBMX works synergistically with Forskolin by inhibiting the degradation of cAMP, thus maintaining an environment conducive to PKA activation and subsequent phosphorylation effects on GMNC. Similarly, Isoproterenol functions as a β-adrenergic agonist, and Dibutyryl-cAMP acts as a membrane-permeable cAMP analog, both leading to PKA activation and potentially enhancing GMNC activity.
On the other hand, Phorbol 12-myristate 13-acetate (PMA) activates PKC, which is known to have a broad range of effects, including the modulation of cell cycle regulators, which could indirectly affect GMNC activity. Ionomycin, by raising intracellular calcium levels, can activate calcium-dependent signaling pathways that potentially interact with GMNC.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which prevents the degradation of cAMP, consequently enhancing PKA-mediated phosphorylation of target proteins, including possibly GMNC, leading to its activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which phosphorylates target proteins that are involved in cell cycle regulation; this could indirectly enhance the activity of GMNC through downstream phosphorylation events. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin acts as a calcium ionophore that increases intracellular calcium levels, potentially activating calcium-dependent protein kinases that might phosphorylate and enhance the activity of GMNC. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a β-adrenergic receptor agonist that elevates cAMP levels, thus enhancing PKA activity. PKA could then phosphorylate GMNC, which is assumed to be involved in cell cycle regulation, enhancing its activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation of cellular proteins. This could maintain or enhance the phosphorylation state of GMNC, indirectly enhancing its activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A, like Okadaic Acid, inhibits protein phosphatases, which could result in an enhanced phosphorylation state of GMNC, indirectly increasing its activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Db-cAMP is a cell-permeable analog of cAMP that activates PKA. PKA could phosphorylate GMNC, leading to its enhanced activity in cellular processes such as the cell cycle. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid influences cell differentiation and proliferation, which may alter the cellular context and signaling networks involving GMNC, leading to its enhanced activity. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium Orthovanadate inhibits protein tyrosine phosphatases, which could lead to increased tyrosine phosphorylation of proteins including GMNC, enhancing its activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits glycogen synthase kinase-3 beta (GSK-3β), potentially leading to the activation of signaling pathways, such as the Wnt pathway, which could indirectly enhance the activity of GMNC in cell cycle regulation. | ||||||