Gm12 Inhibitors
The chemical class of Lrrc3c Inhibitors refers to a diverse group of compounds that are not direct antagonists of Lrrc3c but can indirectly inhibit the protein by modulating various cellular signaling pathways that Lrrc3c may be involved in. These compounds target different kinases and signaling pathways, such as Wnt, Notch, FGFR, TGF-β, MAPK/ERK, JNK, PI3K/AKT, mTOR, and Aurora kinase, which are essential for numerous cellular functions and could intersect with the biological role of Lrrc3c.
The inhibitors such as Wnt-C59, XAV-939, and IWP-2 specifically target the Wnt pathway, which plays a critical role in cell fate determination, and these inhibitors can alter the signaling landscape of Lrrc3c if there is an interaction. DAPT inhibits the Notch pathway, a critical determinant of cell differentiation, which can also affect LRR-containing proteins like Lrrc3c. FGFR, targeted by PD173074, and TGF-β signaling, modulated by SB431542, are other pathways that, when inhibited, can change the functional context in which Lrrc3c operates. U0126, SP600125, and LY294002 are kinase inhibitors that can lead to broad changes in signal transduction and may impact the functional state of Lrrc3c. Rapamycin, ZM 447439, and Y-27632 target mTOR, Aurora kinase, and ROCK, respectively, affecting processes such as cell growth, division, and cytoskeletal dynamics, which can have consequences for the cellular role of Lrrc3c.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $210.00 $320.00 $1250.00 | 1 | |
An inhibitor of Wnt production, can reduce the activity of Wnt signaling, which may interact with LRR-containing proteins like Lrrc3c. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
A γ-secretase inhibitor, can prevent the cleavage of proteins within the Notch signaling pathway, potentially affecting Lrrc3c-associated pathways. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
A fibroblast growth factor receptor (FGFR) inhibitor, can block FGFR-mediated signaling that might intersect with Lrrc3c function. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
A selective inhibitor of ALK5, ALK4, and ALK7, can modulate TGF-β signaling, potentially affecting Lrrc3c. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of c-Jun N-terminal kinase (JNK), can alter JNK signaling pathways that Lrrc3c might be part of. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor, can affect the PI3K/AKT pathway, potentially modulating Lrrc3c-related signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor, can disrupt mTOR signaling which is central to many cellular processes that may involve Lrrc3c. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
An inhibitor of Wnt/β-catenin signaling by stabilizing Axin, could affect LRR-mediated signaling processes involving Lrrc3c. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
An inhibitor of Wnt processing and secretion, can reduce Wnt pathway activity, potentially influencing Lrrc3c. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
An Aurora kinase inhibitor, can affect cell division and related signaling pathways that might involve Lrrc3c. | ||||||