Gm12 Activators
Leucine-rich repeat-containing 3C (LRRC3C) activators encompass a range of chemical compounds that influence cellular signaling pathways, ultimately leading to the enhancement of LRRC3C activity. Compounds like forskolin and prostaglandin E2 (PGE2) function by increasing intracellular levels of cAMP, which in turn activates protein kinase A (PKA). Activated PKA can then phosphorylate various proteins that are pertinent to the regulation of LRRC3C, thereby enhancing its function. Similarly, phosphodiesterase inhibitors such as IBMX, rolipram, zaprinast, sildenafil, and vardenafil raise the levels of cyclic nucleotides (cAMP or cGMP), leading to activation of PKA or protein kinase G (PKG). The activation of these kinases potentially enhances LRRC3C activity through phosphorylation of associated regulatory proteins.
Other compounds work via modulating cellular calcium levels, which is another crucial signaling molecule that can influence LRRC3C activity. A23187 (calcimycin) increases intracellular calcium, which could activate calcium-dependent kinases or binding proteins that interact with LRRC3C, leading to its functional activation. Conversely,BAPTA-AM serves to regulate intracellular calcium levels by chelating calcium ions, thus affecting kinases and phosphatases that are calcium-dependent, which in turn could enhance LRRC3C function. Finally, okadaic acid inhibits protein phosphatases 1 and 2A, which usually dephosphorylate proteins, thereby maintaining a higher phosphorylation state within the cell. This inhibition could prevent the dephosphorylation of proteins that modulate LRRC3C activity, resulting in an enhanced functional state of LRRC3C.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits phosphodiesterases, leading to an increase in cAMP levels. Higher cAMP can activate PKA, which may then enhance the activity of LRRC3C through downstream phosphorylation events. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, causing an increase in cAMP and subsequent activation of PKA, potentially enhancing the activity of LRRC3C. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) activates its G-protein-coupled EP receptors, leading to increased intracellular cAMP and activation of PKA, which may then enhance LRRC3C activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits PDE4, leading to increased cAMP levels and PKA activation. PKA can phosphorylate proteins involved in LRRC3C regulation, enhancing its activity. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
Zaprinast inhibits PDE5, increasing cAMP levels which may enhance PKA activity and subsequently upregulate LRRC3C activity through phosphorylation of associated regulatory proteins. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $31.00 $61.00 $219.00 $352.00 | 2 | |
L-Arginine is a substrate for nitric oxide synthase, leading to production of nitric oxide which can activate guanylyl cyclase, increasing cGMP and activating PKG. PKG may enhance LRRC3C activity through downstream signaling effects. | ||||||
Vardenafil | 224785-90-4 | sc-362054 sc-362054A sc-362054B | 100 mg 1 g 50 g | $526.00 $735.00 $16653.00 | 7 | |
Vardenafil, by inhibiting PDE5, increases cGMP levels which can activate PKG. The activation of PKG may enhance the function of LRRC3C through downstream signaling cascades. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 acts as a calcium ionophore, increasing intracellular calcium levels and potentially enhancing the activity of calcium-dependent proteins that could influence LRRC3C function. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a cell-permeable calcium chelator that can modulate calcium signaling. Adjusting calcium levels can affect calcium-dependent kinases and phosphatases that regulate LRRC3C. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of cellular proteins, which may result in enhanced activity of LRRC3C through reduced dephosphorylation. | ||||||