Glut14 Inhibitors
Glut14 Inhibitors primarily operate by obstructing the glucose transport pathway. Compounds such as Phloretin, Quercetin, and Apigenin are flavonoids that can inhibit GLUTs, including Glut14. They act by blocking the glucose transport pathway, thus reducing the transportation of glucose and indirectly inhibiting Glut14. Cytochalasin B, a potent inhibitor of actin polymerization, can influence glucose transportation by disrupting the actin cytoskeleton, a component necessary for GLUT translocation. This disruption indirectly leads to the inhibition of Glut14. Meanwhile, Genipin, a natural crosslinker that can inhibit uncoupling proteins like UCP2, can indirectly affect the function of Glut14, given the interaction between Glut14 and UCP2.
Simultaneously, Glut14 inhibitors may target the glucose transport pathway through competitive inhibition among the GLUT family members. Inhibitors such as STF-31, WZB117, BAY-876, and Ritonavir inhibit other GLUTs, notably GLUT1 and GLUT4, reducing glucose transport and creating a competitive environment among the GLUT family members. This competition indirectly leads to the inhibition of Glut14. Similarly, Fasentin, which sensitizes cells to apoptosis induced by FasL and inhibits GLUT1, could indirectly inhibit Glut14 by creating a competitive environment among the GLUT family members. Lastly, Pf-06424439 and Azaserine inhibit key enzymes and pathways in glucose metabolism, leading to reduced glucose uptake and the indirect inhibition of Glut14.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phloretin | 60-82-2 | sc-3548 sc-3548A | 200 mg 1 g | $63.00 $250.00 | 13 | |
Phloretin is a dihydrochalcone flavonoid that can inhibit GLUTs, including Glut14. It acts by blocking the glucose transport pathway, thus reducing the transportation of glucose and indirectly inhibiting Glut14. | ||||||
Cytochalasin B | 14930-96-2 | sc-3519 | 5 mg | $195.00 | 19 | |
Cytochalasin B is a potent inhibitor of actin polymerization. It can influence glucose transportation by disrupting the actin cytoskeleton, a component necessary for GLUT translocation, indirectly leading to the inhibition of Glut14. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid that can inhibit GLUTs, including Glut14. It works by blocking the glucose transport pathway, which indirectly inhibits Glut14. | ||||||
Genipin | 6902-77-8 | sc-203057 sc-203057A | 25 mg 100 mg | $80.00 $246.00 | 6 | |
Genipin is a natural crosslinker that can inhibit uncoupling proteins like UCP2. As Glut14 has been shown to interact with UCP2, its inhibition could indirectly affect the function of Glut14. | ||||||
STF 31 | 724741-75-7 | sc-364692 | 10 mg | $183.00 | 3 | |
STF-31 is a selective inhibitor of GLUT1. It can indirectly inhibit Glut14 by reducing glucose transport and creating a competitive environment among the GLUT family members. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $48.00 $122.00 $432.00 $812.00 | 4 | |
WZB117 is a GLUT1 inhibitor that can indirectly inhibit Glut14. By reducing glucose transport, it creates an environment where GLUT family members compete for function, indirectly leading to the inhibition of Glut14. | ||||||
BAY-876 | 1799753-84-6 | sc-507539 | 5 mg | $240.00 | ||
BAY-876 is a GLUT1 inhibitor that can indirectly inhibit Glut14 by reducing glucose transportation. This creates a competitive environment among the GLUT family members, indirectly leading to the inhibition of Glut14. | ||||||
Ritonavir | 155213-67-5 | sc-208310 | 10 mg | $122.00 | 7 | |
Ritonavir is an antiretroviral drug that can inhibit GLUT4. The inhibition of GLUT4 causes a competitive environment among the GLUT family members, indirectly leading to the inhibition of Glut14. | ||||||
Fasentin | 392721-37-8 | sc-215012 sc-215012A | 5 mg 25 mg | $125.00 $440.00 | ||
Fasentin is a compound that sensitizes cells to apoptosis induced by FasL. It can also inhibit GLUT1, which could indirectly inhibit Glut14 by creating a competitive environment among the GLUT family members. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin is a flavonoid that can inhibit GLUTs, including Glut14. It works by blocking the glucose transport pathway, which indirectly inhibits Glut14. | ||||||