Ritonavir is an inhibitor of HIV-1 protease used to treat HIV infection and AIDS. Currently rarely used for its own antiviral activity, but remains widely used as a booster of other protease inhibitors. More specifically, ritonavir is used to inhibit a particular liver enzyme that normally metabolizes protease inhibitors, CYP3A4 (cytochrome P450-3A4).
Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994), Ammaranond, P., et al.: J. Clin. Virol., 26, 153 (2003), Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005), Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788(2006)
Soluble in methanol, water (partly), ethanol (~5 mg/ml), DMF (~15 mg/ml), and DMSO (100 mg/mL at 25° C).
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Lef vreLef vre, C. et al. (PubMed 20884875) used Ritonavir, a selective HIV protease inhibitor, and a combination of lopinavir and Ritonavir to study their effects on senescence, oxidative stress, and inflammation in human coronary artery endothelial cells (HCAECs). Found that Ritonavir triggered premature senescence in endothelial cells by a mechanism involving prelamin A accumulation. -SCBT Publication Review
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