Ritonavir CAS: 155213-67-5
MF: C37H48N6O5S2
MW: 720.94
An inhibitor of HIV-1 protease.

Ritonavir (CAS 155213-67-5)

Ritonavir | CAS 155213-67-5 is rated 5.0 out of 5 by 1.
  • y_2020, m_9, d_17, h_16
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_208310, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 131ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Alternate Names: Norvir, Norvir Softgel
Application: Ritonavir is an inhibitor of HIV-1 protease
CAS Number: 155213-67-5
Purity: ≥98%
Molecular Weight: 720.94
Molecular Formula: C37H48N6O5S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Ritonavir is an inhibitor of HIV-1 protease used to treat HIV infection and AIDS. Currently rarely used for its own antiviral activity, but remains widely used as a booster of other protease inhibitors. More specifically, ritonavir is used to inhibit a particular liver enzyme that normally metabolizes protease inhibitors, CYP3A4 (cytochrome P450-3A4).


References

Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994), Ammaranond, P., et al.: J. Clin. Virol., 26, 153 (2003), Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005), Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788(2006)

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in methanol, water (partly), ethanol (~5 mg/ml), DMF (~15 mg/ml), and DMSO (100 mg/mL at 25° C).
Storage :
Store at 4° C
Melting Point :
120-122° C
Boiling Point :
~947° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.6 (Predicted)
IC50 :
MT2: IC50 = 10 nM (human); MT4: IC50 = 10 nM (human); Human immunodeficiency virus 1: IC50 = 15 nM; CYP2C9: IC50 = 16 nM (human); CYP3A4: IC50 = 16 nM (human)
Ki Data :
Human immunodeficiency virus type 1 protease: Ki= 15 pM (Human immunodeficiency virus 1); CYP3A4: Ki= 100 nM (human); CYP3A5: Ki= 120 nM (human); NK-2R: Ki= 0.87 µM (human); AVP Receptor V1a: Ki= 4.98 µM (human)
pK Values :
pKa: 11.47 (Predicted), pKb: 2.51 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
XA5310000
PubChem CID :
392622
MDL Number :
MFCD00927142
SMILES :
CC(C)C1=NC(=CS1)CN(C)C(=O)N[[email protected]@H](C(C)C)C(=O)N[[email protected]@H](CC2=CC=CC=C2)C[[email protected]@H]([[email protected]](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Ritonavir (CAS 155213-67-5)  Product Citations

See how others have used Ritonavir (CAS 155213-67-5). Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 31133852  Bresciani, E. et al. 2019. Front Pharmacol. 10: 461.

PMID: # 23750830  Chang, JH. et al. 2013. Mol. Pharm. 10: 3067-75.

PMID: # 23143674  Nishimura, T. et al. 2013. The Journal of pharmacology and experimental therapeutics. 344: 388-96.

PMID: # 21068005  Leroyer, S. et al. 2011. J. Lipid Res. 52: 207-20.

PMID: # 20884875  Lefèvre C et al. 2010. Arterioscler Thromb Vasc Biol. 30: 2611-2620.

Citations 1 to 5 of 5 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 115ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Lef vre Lef vre, C. et al. (PubMed 20884875) used Ritonavir, a selective HIV protease inhibitor, and a combination of lopinavir and Ritonavir to study their effects on senescence, oxidative stress, and inflammation in human coronary artery endothelial cells (HCAECs). Found that Ritonavir triggered premature senescence in endothelial cells by a mechanism involving prelamin A accumulation. -SCBT Publication Review
Date published: 2015-02-27
  • y_2020, m_9, d_17, h_16
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_208310, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 9ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.