Molecular structure of STF 31, CAS Number: 724741-75-7
STF 31 (CAS 724741-75-7)
See product citations (3)
Alternate Names:
4-[[[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinylbenzamide
Application:
STF 31 is a Glut1 and glucose uptake inhibitor
CAS Number:
724741-75-7
Purity:
≥99%
Molecular Weight:
423.53
Molecular Formula:
C23H25N3O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
STF 31 is a small molecule that has shown great potential in various scientific research applications. Extensive research has been conducted on this compound to investigate its biological activity, biochemical and physiological effects, and mechanism of action. Scientists have optimized the synthesis method of STF 31 to enhance its potency and effectiveness in laboratory experiments. In vitro studies have demonstrated its ability to regulate the activity of several proteins such as protein kinases and proteases, and also to suppress the proliferation of cancer cells.
STF 31 (CAS 724741-75-7) References
- Estrogen inhibits NPY secretion through membrane-associated estrogen receptor (ER)-α in clonal, immortalized hypothalamic neurons. | Dhillon, SS. and Belsham, DD. 2011. Int J Obes (Lond). 35: 198-207. PMID: 20548307
- Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. | Chan, DA., et al. 2011. Sci Transl Med. 3: 94ra70. PMID: 21813754
- Kidney cancer: targeted therapy of glucose uptake via GLUT1 kills RCC cells. | Ozerlat, I. 2011. Nat Rev Urol. 8: 471. PMID: 21901019
- A sweet blow for cancer cells. | Flight, MH. 2011. Nat Rev Drug Discov. 10: 734. PMID: 21959286
- NAMPT is the cellular target of STF-31-like small-molecule probes. | Adams, DJ., et al. 2014. ACS Chem Biol. 9: 2247-54. PMID: 25058389
- A human pluripotent stem cell surface N-glycoproteome resource reveals markers, extracellular epitopes, and drug targets. | Boheler, KR., et al. 2014. Stem Cell Reports. 3: 185-203. PMID: 25068131
- Inhibition of an NAD⁺ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells. | Kropp, EM., et al. 2015. Stem Cells Transl Med. 4: 483-93. PMID: 25834119
- Inhibition of glucose transporter 1 induces apoptosis and sensitizes multiple myeloma cells to conventional chemotherapeutic agents. | Matsumoto, T., et al. 2016. Leuk Res. 41: 103-10. PMID: 26790725
- A Red-Light-Activated Ruthenium-Caged NAMPT Inhibitor Remains Phototoxic in Hypoxic Cancer Cells. | Lameijer, LN., et al. 2017. Angew Chem Int Ed Engl. 56: 11549-11553. PMID: 28666065
- Hypoxia increases glucose transporter 1 expression in bovine corpus luteum at the early luteal stage. | Nishimura, R., et al. 2017. J Vet Med Sci. 79: 1878-1883. PMID: 29046497
- Dynamic Profiling of Insulin Secretion and ATP Generation in Isolated Human and Mouse Islets Reveals Differential Glucose Sensitivity. | Pingitore, A., et al. 2017. Cell Physiol Biochem. 44: 1352-1359. PMID: 29186709
- Targeting glucose transport and the NAD pathway in tumor cells with STF-31: a re-evaluation. | Kraus, D., et al. 2018. Cell Oncol (Dordr). 41: 485-494. PMID: 29949049
- A mixture of persistent organic pollutants detected in human follicular fluid increases progesterone secretion and mitochondrial activity in human granulosa HGrC1 cells. | Krawczyk, K., et al. 2021. Reprod Toxicol. 104: 114-124. PMID: 34311058
- A Lock-and-Kill Anticancer Photoactivated Chemotherapy Agent†. | van Geest, EP., et al. 2023. Photochem Photobiol. 99: 777-786. PMID: 36315051
- Targeting of Glucose Transport and the NAD Pathway in Neuroendocrine Tumor (NET) Cells Reveals New Treatment Options. | Winter, J., et al. 2023. Cancers (Basel). 15: PMID: 36900207
Inhibitor of:
γ-GCSc, AsnRS, CARKL, GalNAc-T6, Glut1, Glut10, Glut11, Glut12, Glut14, Glut2, Glut3, Glut5, Glut7, Glut8, GLYATL3, H6PD, Hex, HXK II, HXK III, N6AMT2, NaGLT1, Naglt1c, NARS2, NMNAT-1, SFXN2, SLC-1, SLC43A1, and TKTL2.Activator of:
GNPDA2, GnT-I, LDHA, and LDHB.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
STF 31, 10 mg | sc-364692 | 10 mg | $187.00 |