Molecular structure of Cytochalasin B, CAS Number: 14930-96-2
Cytochalasin B (CAS 14930-96-2)
See product citations (19)
Alternate Names:
Cytochalasin B is also known as Phomin.
Application:
Cytochalasin B is a cell-permeable fungal toxin used in actin polymerization studies and cytological research.
CAS Number:
14930-96-2
Purity:
≥98%
Molecular Weight:
479.61
Molecular Formula:
C29H37NO5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cytochalasin B is used in actin polymerization studies. It is a metabolite of the fungus Drechslera dematoidea which binds to the barbed end of actin filaments resulting in inhibition of both the association and dissociation of subunits. Cytochalasin B is used as a tool for cytological research. As opposed to other Cytochalasins, cytochalasin A (sc-204705) and Cytochalasin B bind to the glucose transporter and inhibit monosaccharide transport across the plasma membrane. Cytochalasin B inhibits phagocytosis by both mononuclear phagocytes and polymorphonuclear leukocytes. Cytochalasin B is also known as Phomin, NSC 107658, and (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione.
Cytochalasin B (CAS 14930-96-2) References
- The inhibition of GLUT1 glucose transport and cytochalasin B binding activity by tricyclic antidepressants. | Pinkofsky, HB., et al. 2000. Life Sci. 66: 271-8. PMID: 10666003
- Effect of cytochalasin B on glucose uptake, utilization, oxidation and insulinotropic action in tumoral insulin-producing cells. | Malaisse, WJ., et al. 1987. Cell Biochem Funct. 5: 183-7. PMID: 3038362
- Route to Rheumatoid Arthritis by Macrophage-Derived Microvesicle-Coated Nanoparticles. | Li, R., et al. 2019. Nano Lett. 19: 124-134. PMID: 30521345
- Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis. | Gaul, S., et al. 2021. J Hepatol. 74: 156-167. PMID: 32763266
- Effects of cytochalasin and phalloidin on actin. | Cooper, JA. 1987. J Cell Biol. 105: 1473-8. PMID: 3312229
- Cytochalasin B-induced membrane vesicles from human mesenchymal stem cells overexpressing TRAIL, PTEN and IFN-β1 can kill carcinoma cancer cells. | Chulpanova, DS., et al. 2021. Tissue Cell. 73: 101664. PMID: 34678531
- Cytochalasin B Treatment and Osmotic Pressure Enhance the Production of Extracellular Vesicles (EVs) with Improved Drug Loading Capacity. | Nair, A., et al. 2021. Nanomaterials (Basel). 12: PMID: 35009953
- Effects of cytochalasin B on endocytosis and exocytosis. | Davies, P. and Allison, AC. 1978. Front Biol. 46: 143-60. PMID: 352738
- Cryo-EM structure of human glucose transporter GLUT4. | Yuan, Y., et al. 2022. Nat Commun. 13: 2671. PMID: 35562357
- Cytochalasin B Modulates Nanomechanical Patterning and Fate in Human Adipose-Derived Stem Cells. | Bianconi, E., et al. 2022. Cells. 11: PMID: 35626666
- Mitochondrial aggregation caused by cytochalasin B compromises the efficiency and safety of three-parent embryo. | Li, Y., et al. 2022. Mol Hum Reprod. 28: PMID: 36264122
- Cytochalasin B: effects on cell morphology, cell adhesion, and mucopolysaccharide synthesis (cultured cells-contractile microfilaments-glycoproteins-embryonic cells-sorting-out). | Sanger, JW. and Holtzer, H. 1972. Proc Natl Acad Sci U S A. 69: 253-7. PMID: 4257818
- Cytochalasin B: inhibition of glucose and glucosamine transport. | Ebstensen, RD. and Plagemann, PG. 1972. Proc Natl Acad Sci U S A. 69: 1430-4. PMID: 4338593
- Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping. | Theodoropoulos, PA., et al. 1994. Biochem Pharmacol. 47: 1875-81. PMID: 8204105
Inhibitor of:
ACTA1, ACTG1, Arp3β, Gelsolin, Glut11, Glut14, Glut4, Glut5, Glut7, NaGLT1, SLC-1, Tmsb15b1, transgelin-2, and Wip1.Activator of:
EG433102, Glut9, HepaCAM, Septin 4, and tropomodulin 4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytochalasin B, 5 mg | sc-3519 | 5 mg | $195.00 |