Cytochalasin B CAS: 14930-96-2
MF: C29H37NO5
MW: 479.61

Cytochalasin B (CAS 14930-96-2)

Cytochalasin B | CAS 14930-96-2 is rated 5.0 out of 5 by 1.
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Alternate Names: Cytochalasin B is also known as Phomin.
Application: Cytochalasin B is a cell-permeable fungal toxin used in actin polymerization studies and cytological research.
CAS Number: 14930-96-2
Purity: ≥98%
Molecular Weight: 479.61
Molecular Formula: C29H37NO5
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Cytochalasin B is used in actin polymerization studies. Cytochalasin B is a metabolite of the fungus Drechslera dematoidea which binds to the barbed end of actin filaments resulting in inhibition of both the association and dissociation of subunits. Cytochalasin B is used as a tool for cytological research. As opposed to other Cytochalasins, cytochalasin A (sc-204705) and Cytochalasin B bind to the glucose transporter and inhibit monosaccharide transport across the plasma membrane. Cytochalasin B inhibits phagocytosis by both mononuclear phagocytes and polymorphonuclear leukocytes. Cytochalasin B is also known as Phomin, NSC 107658, and (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione.


References

1. Sanger, J.W., et al. 1972. Proc. Natl. Acad. Sci. U.S.A. 69: 253-257. PMID: 4257818

2. Ebstensen, R.D., et al. 1972. Proc. Natl. Acad. Sci. U.S.A. 69: 1430-1434. PMID: 4338593

3. Davies, P., et al. 1978. Front Biol. 46: 143-160. PMID: 352738

4. Malaisse, W.J., et al. 1987. Cell Biochem. Funct. 5: 183-187. PMID: 3038362

5. Cooper, J.A., et al. 1987. J. Cell Biol. 105: 1473-1478. PMID: 3312229

6. Theodoropoulos, P.A., et al. 1994. Biochem. Pharmacol. 47: 1875-1881. PMID: 8204105

7. Pinkofsky, H.B., et al. 2000. Life Sci. 66: 271-278. PMID: 10666003

Usage :
In solid form, Cytochalasin B is believed to be photostable, and reasonably stable in solution.

Cytochalasins are regarded as highly toxic and possible teratogens. Handle in a manner to avoid/minimize direct body contact and inhalation.
Physical State :
Solid
Derived From :
Drechslera dematoidea
Solubility :
Soluble in methanol (20 mg/ml), and 1:20 DMF:PBS(7.2) (~0.05 mg/ml).
Storage :
Store at -20° C
Melting Point :
221-223° C
Boiling Point :
740.56° C at 760 mmHg (Predicted)
Density :
1.21 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
RO0205000
PubChem CID :
2919
Merck Index :
14: 2790
MDL Number :
MFCD00077704
EC Number :
239-000-2
Beilstein Registry :
1096207

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Certificate of Analysis

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Cytochalasin B (CAS 14930-96-2)  Product Citations

See how others have used Cytochalasin B (CAS 14930-96-2). Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 27382603  Liskovykh, M. et al. 2016. Molecular therapy. Methods & clinical development. 3: 16043.

PMID: # 29195861  Zhou, C.|Wang, Y.|Pan, D.|Sun, Y.|Cao, J.| et al. 2016. Food Res. Int. 90: 1-7.

PMID: # 23151802  Lee, JE. et al. 2013. American journal of physiology. Cell physiology. 304: C312-23.

PMID: # 10780954  Lin, Z. et al. 2000. Am. J. Physiol. Endocrinol. Metab. 278: E958-E966.

PMID: # 32503669  BMC Vet. Res. 16: 179.

PMID: # 31699974  Cell Death Dis. 10: 850.

Citations 1 to 6 of 6 total

Is this cell culture grade? Suitable for Cytokinesis blocked micronucleus assay? Thanks

Asked by: Sonal
This product has not been specifically tested for cell culture use and is not cell culture grade, however, most products can still be used in cell culture applications by following basic cell culture protocols, e.g. using cell culture grade/sterilized solvents, aseptic technique, and sterilely filtering in a sterile hood. It has not been tested for Cytokinesis blocked micronucleus assay.
Answered by: Tech Service
Date published: 2020-02-07

What is your local distributor in Egypt and how much is the price after adding the shipping charge?

Asked by: omaima ibrahim
Thank you for your inquiry and your interest in our products. For quotations, please contact our costumer care by phone or by live chat, or visiting our website www.scbt.com to find our local distributor.
Answered by: SCBT Heidelberg Support
Date published: 2019-03-05

Can I use DMSO as a solvent?

Asked by: SCM4
This chemical, Cytochalasin B (CAS 14930-96-2), is soluble in DMSO (20 mg/mL), which should be purged with an inert gas.
Answered by: Chemical Support 1
Date published: 2017-03-24
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Rated 5 out of 5 by from Lin Lin, et. al. (PubMed ID 10780954) found that treating cells with cytochalasin to irreversibly block glucose uptake, apoptosis proceeded without any roadblocks. -SCBT Publication Review
Date published: 2015-01-31
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