Molecular structure of BAY-876, CAS Number: 1799753-84-6
BAY-876 (CAS 1799753-84-6)
Alternate Names:
BAY 876 N4-[1-[(4-cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-Quinolinedicarboxamide BAY876
CAS Number:
1799753-84-6
Molecular Weight:
496.40
Molecular Formula:
C24H16F4N6O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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BAY-876 (CAS 1799753-84-6) References
- Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876. | Siebeneicher, H., et al. 2016. ChemMedChem. 11: 2261-2271. PMID: 27552707
- Ovarian Cancer Relies on Glucose Transporter 1 to Fuel Glycolysis and Growth: Anti-Tumor Activity of BAY-876. | Ma, Y., et al. 2018. Cancers (Basel). 11: PMID: 30602670
- GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer. | Wu, Q., et al. 2020. Nat Commun. 11: 4205. PMID: 32826891
- A Novel Microcrystalline BAY-876 Formulation Achieves Long-Acting Antitumor Activity Against Aerobic Glycolysis and Proliferation of Hepatocellular Carcinoma. | Yang, H., et al. 2021. Front Oncol. 11: 783194. PMID: 34869036
- Diaminobutoxy-substituted Isoflavonoid (DBI-1) Enhances the Therapeutic Efficacy of GLUT1 Inhibitor BAY-876 by Modulating Metabolic Pathways in Colon Cancer Cells. | Guo, L., et al. 2022. Mol Cancer Ther. 21: 740-750. PMID: 35247917
- Muscle-Specific Ablation of Glucose Transporter 1 (GLUT1) Does Not Impair Basal or Overload-Stimulated Skeletal Muscle Glucose Uptake. | McMillin, SL., et al. 2022. Biomolecules. 12: PMID: 36551162
- Characterization of the effect of the GLUT-1 inhibitor BAY-876 on T cells and macrophages. | Chen, Z., et al. 2023. Eur J Pharmacol. 945: 175552. PMID: 36739076
- BMP4 upregulates glycogen synthesis through the SMAD/SLC2A1 (GLUT1) signaling axis in hepatocellular carcinoma (HCC) cells. | Zhong, J., et al. 2023. Cancer Metab. 11: 9. PMID: 37443106
- Metabolism/Immunity Dual-Regulation Thermogels Potentiating Immunotherapy of Glioblastoma Through Lactate-Excretion Inhibition and PD-1/PD-L1 Blockade. | Li, T., et al. 2024. Adv Sci (Weinh). 11: e2310163. PMID: 38460167
- Hyperglycemia enhances brain susceptibility to lipopolysaccharide-induced neuroinflammation via astrocyte reprogramming. | Lee, KS., et al. 2024. J Neuroinflammation. 21: 137. PMID: 38802820
Inhibitor of:
Amylase 2A, Amylase 2B, ChREBP, Glut1, Glut14, Glut2, Glut7, IER2, PEPCK-C, PYGB, PYGL, SLC-1, TREML6, and TSHZ2.Activator of:
ACTR6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BAY-876, 5 mg | sc-507539 | 5 mg | $240.00 |