Date published: 2025-10-22

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Glut1 Inhibitors

Glut1 inhibitors belong to a significant class of compounds that primarily target Glucose Transporter 1 (Glut1) proteins, instrumental in facilitating the transport of glucose across cell membranes. Glut1, a transmembrane protein, is particularly abundant in various tissues, playing a pivotal role in glucose uptake and maintenance of glucose homeostasis. Glut1 inhibitors are designed to modulate this glucose transport process by interacting with the Glut1 proteins. Structurally diverse, Glut1 inhibitors exhibit distinct mechanisms of action to impede the normal function of Glut1 proteins. These inhibitors are specifically designed to bind to the active site of Glut1, thereby hindering glucose transport through the membrane. By doing so, they influence the intracellular glucose concentration, which in turn may impact various cellular processes. While the structural intricacies of these inhibitors may vary, their common objective is to prevent glucose from entering the cells, thus leading to downstream effects that could be relevant in a variety of contexts.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

STF 31

724741-75-7sc-364692
10 mg
$183.00
3
(1)

STF-31 targets GLUT1 by inhibiting glucose uptake and inducing cell death in cancer cells through AMPK activation and mTOR inhibition.

Fasentin

392721-37-8sc-215012
sc-215012A
5 mg
25 mg
$125.00
$440.00
(0)

Fasentin (CAS 392721-37-8) is a chemical compound known for its role as a Glut1 inhibitor, impacting cellular glucose uptake. It modulates Glut1 function, influencing glucose transport processes.

Wiskostatin

253449-04-6sc-204399
sc-204399A
sc-204399B
sc-204399C
1 mg
5 mg
25 mg
50 mg
$48.00
$122.00
$432.00
$812.00
4
(1)

WZB117 inhibits GLUT1 by disrupting its trafficking to the cell membrane, thereby reducing glucose uptake in cancer cells.

BAY-876

1799753-84-6sc-507539
5 mg
$240.00
(0)

BAY-876 is a selective GLUT1 inhibitor that impairs glucose uptake in cancer cells, leading to metabolic stress and inhibition of tumor growth.

Phloretin

60-82-2sc-3548
sc-3548A
200 mg
1 g
$63.00
$250.00
13
(1)

Phloretin inhibits GLUT1 by binding to its glucose-binding site, preventing glucose transport across the cell membrane.