GIMAP1 Activators
GIMAP1 Activators are a set of chemical compounds that indirectly enhance the functional activity of GIMAP1 by modulating various cellular signaling pathways. Forskolin, by increasing intracellular cAMP levels, indirectly activates GIMAP1 through the activation of protein kinase A (PKA), which phosphorylates proteins within immune cells, potentially enhancing GIMAP1's role in lymphocyte survival. Similarly, Dibutyryl cyclic AMP, a stable cAMP analog, and Isoproterenol, a beta-adrenergic receptor agonist, elevate cAMP levels, thereby activating PKA and influencing pathways that intersect with GIMAP1's function. PMA, as an activator of protein kinase C (PKC), and BIM, a PKC inhibitor, both impact T-cell receptor signaling, altering the activation state of GIMAP1. Calcium ionophores like Ionomycin and A23187 raise intracellular calcium levels, potentially enhancing GIMAP1 function by activating calcium-dependent signaling pathways related to T-cell activation. Prostaglandin E2, by interacting with its receptors, also increases cAMP levels, and together with Rolipram, a PDE4 inhibitor, they augment GIMAP1 activity by modulating T-cell receptor signaling.
In addition to these, LY294002 and U0126 target the PI3K/Akt and MAPK/ERK pathways, respectively, both of which are crucial for T-cell development and survival, thereby indirectly enhancing GIMAP1 activity. LY294002's inhibition of PI3K and U0126's inhibition of MEK1/2 alter the balance of survival and apoptotic signals, which can lead to an enhancement of GIMAP1's role in immune cell regulation. Finally, Okadaic acid, by inhibiting protein phosphatases PP1 and PP2A, changes the phosphorylation landscape within T-cell signaling pathways, potentially resulting in the enhanced activity of GIMAP1. Collectively, these GIMAP1 Activators influence a variety of intracellular signaling mechanisms, leading to the indirect enhancement of GIMAP1's role in the regulation of the immune system, particularly affecting T-cell survival and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, resulting in increased levels of cyclic AMP (cAMP) in cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate a range of proteins, enhancing the activity of GIMAP1 through phosphorylation-dependent mechanisms within immune cells. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
This synthetic analog of cAMP is resistant to degradation by phosphodiesterases and effectively elevates intracellular cAMP levels. This activates PKA, which could enhance GIMAP1 activity through downstream phosphorylation events, particularly in pathways related to lymphocyte survival and homeostasis. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC activation can lead to the phosphorylation of proteins involved in signaling pathways that intersect with GIMAP1 functions, such as T-cell receptor (TCR) signaling, thus indirectly enhancing GIMAP1 activity by modulating T-cell activation and apoptosis. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calcineurin and subsequent downstream pathways, such as the NFAT signaling pathway, which can interact with pathways involving GIMAP1, thereby indirectly enhancing its functional activity in T-cell activation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Similar to ionomycin, A23187 is a calcium ionophore, raising intracellular calcium levels and potentially affecting calcium-dependent signaling pathways. This can indirectly enhance GIMAP1 activity by activating T-cell signaling mechanisms where GIMAP1 is implicated, particularly in the context of immune response regulation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic receptor agonist that increases intracellular cAMP levels. This elevation could activate PKA, thus influencing signaling pathways that involve GIMAP1, leading to its enhanced activity in immune cells, particularly those where adrenergic signaling plays a regulatory role. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3K). Inhibition of PI3K can modulate downstream signaling pathways, such as Akt, which intersects with survival and apoptosis pathways in which GIMAP1 is involved. This can lead to an indirect enhancement of GIMAP1 activity in T-cells. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, leading to the suppression of ERK phosphorylation. By modulating the MAPK/ERK pathway, U0126 can influence signaling pathways that intersect with GIMAP1’s role, particularly in T-cell development and survival, potentially enhancing GIMAP1 activity. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
BIM is a selective inhibitor of PKC. By inhibiting PKC, BIM can alter T-cell receptor-mediated signaling pathways, which may indirectly lead to the enhancement of GIMAP1 activity by modifying the signaling environment in which GIMAP1 operates within T-cells. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2, through its interaction with E-prostanoid receptors, can lead to increased intracellular cAMP levels. As with other cAMP elevating compounds, this can activate PKA and modulate T-cell receptor signaling, indirectly enhancing GIMAP1 activity by influencing T-cell survival and function. | ||||||