Gelsolin Activators
Gelsolin is a multifunctional actin-binding protein found in vertebrates and plays a pivotal role in the dynamic restructuring of the actin cytoskeleton. It contributes to various cellular activities including motility, morphogenesis, and the regulation of intracellular signaling pathways. One of the notable characteristics of gelsolin is its capacity to sever actin filaments, cap the barbed ends, and nucleate actin polymerization. Its activity is regulated by multiple factors, primarily by calcium ions (Ca^2+) and phosphoinositides. In the presence of these ligands, gelsolin undergoes conformational changes that either activate or inhibit its actin-binding and severing abilities. Gelsolin activators, as the name implies, are molecules that enhance the activity of gelsolin, often by facilitating the necessary conformational changes or by increasing its affinity for actin.
Gelsolin activators can be found in various sources, including small molecules, peptides, or even alterations in the local cellular environment. The mechanism through which these activators work may vary. Some might stabilize the active form of gelsolin or may interact with the binding sites to augment the protein's affinity for actin. Others could act indirectly by modulating the concentration or availability of Ca^2+ or phosphoinositides within the cell. Additionally, post-translational modifications of gelsolin, such as phosphorylation or glycosylation, may play a role in modulating its activity, and certain activators might target these modifications. A comprehensive understanding of gelsolin activators is crucial for unraveling the sophisticated regulatory networks that govern cellular dynamics and homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, plays a key role in cell differentiation and growth. It might stimulate Gelsolin expression as part of its broader effects on the cellular differentiation process. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a compound found in turmeric, can modulate various cellular pathways. It may upregulate Gelsolin by modulating signal transduction pathways related to cell motility and structure. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $272.00 | 18 | |
Tamoxifen, often used in breast cancer therapy, can influence cell growth and differentiation. Its effect on Gelsolin could be linked to its broader impacts on cellular cytoskeletal dynamics. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, a plant-derived compound, elevates cAMP levels in cells. Elevated cAMP can lead to increased Gelsolin expression by altering the intracellular signaling cascade. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, an isoflavone, might modulate Gelsolin expression through its interaction with intracellular signaling pathways related to actin dynamics. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, found in grapes, can influence a wide range of cellular pathways. It may affect Gelsolin expression in context with its modulation of cell survival and differentiation pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, from cruciferous vegetables, is known to affect detoxification enzymes. It might induce Gelsolin as a part of its effects on cellular stress response pathways. | ||||||
Daidzein | 486-66-8 | sc-24001 sc-24001A sc-24001B | 100 mg 500 mg 5 g | $28.00 $79.00 $165.00 | 32 | |
Daidzein, an isoflavone like Genistein, might influence Gelsolin expression by modulating cell signaling pathways related to structural dynamics. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a polyphenol from green tea, has antioxidant properties and can modulate cellular pathways. It might enhance Gelsolin expression as part of its broader effects on cell protection mechanisms. | ||||||
Caffeic Acid | 331-39-5 | sc-200499 sc-200499A | 1 g 5 g | $32.00 $62.00 | 1 | |
Caffeic acid, a polyphenol, might induce Gelsolin expression due to its role in affecting oxidative stress and cytoskeletal organization in cells. | ||||||