Molecular structure of Daidzein, CAS Number: 486-66-8
Daidzein (CAS 486-66-8)
See product citations (32)
Alternate Names:
4′,7-Dihydroxyisoflavone; 7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 7-Hydroxy-3-(4-hydroxyphenyl)chromone
Application:
Daidzein is an inactive analog of genistein, a tyrosine kinase inhibitor and an estrogen receptor activator
CAS Number:
486-66-8
Purity:
≥95%
Molecular Weight:
254.20
Molecular Formula:
C15H10O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Daidzein is a naturally occurring compound classified as an isoflavone, which is found in soybeans and soy products. In research, Daidzein is of interest due to its role in plant biology as a signaling molecule and its involvement in the plant′s defense mechanisms. It is frequently used in studies examining the effects of phytochemicals on plant growth and development. In the field of biochemistry, researchers investigate Daidzein′s interaction with enzymes, proteins, and receptors to elucidate its biochemical pathways and potential influences on cellular functions. Additionally, Daidzein serves as a reference compound in chromatographic and spectrophotometric assays, enabling the identification and quantification of isoflavones in dietary and environmental samples. Its role in modulating gene expression is also a subject of research, particularly in the context of plant genetics and secondary metabolite biosynthesis.
Daidzein (CAS 486-66-8) References
- Daidzein, its effects on impaired glucose and lipid metabolism and vascular inflammation associated with type 2 diabetes. | Das, D., et al. 2018. Biofactors. 44: 407-417. PMID: 30191623
- Genistein, a specific inhibitor of tyrosine-specific protein kinases. | Akiyama, T., et al. 1987. J Biol Chem. 262: 5592-5. PMID: 3106339
- Daidzein promotes milk synthesis and proliferation of mammary epithelial cells via the estrogen receptor α-dependent NFκB1 activation. | Yu, M., et al. 2022. Anim Biotechnol. 33: 43-52. PMID: 32401613
- Daidzein ameliorates diabetic retinopathy in experimental animals. | Laddha, AP. and Kulkarni, YA. 2021. Life Sci. 265: 118779. PMID: 33217441
- Daidzein ameliorates experimental acute reflux esophagitis in rats via regulation of cytokines. | Deng, T., et al. 2021. Pharmazie. 76: 84-91. PMID: 33714284
- Daidzein mitigates myocardial injury in streptozotocin-induced diabetes in rats. | Laddha, AP. and Kulkarni, YA. 2021. Life Sci. 284: 119664. PMID: 34090859
- Daidzein suppresses TGF-β1-induced cardiac fibroblast activation via the TGF-β1/SMAD2/3 signaling pathway. | Shu, J., et al. 2022. Eur J Pharmacol. 919: 174805. PMID: 35151651
- Daidzein Activates Akt Pathway to Promote the Proliferation of Female Germline Stem Cells through Upregulating Clec11a. | Li, F., et al. 2022. Stem Cell Rev Rep. 18: 3021-3032. PMID: 35655001
- Structural requirements for differentiation-induction and growth-inhibition of mouse erythroleukemia cells by isoflavones. | Jing, Y. and Waxman, S. 1995. Anticancer Res. 15: 1147-52. PMID: 7653993
- ADP- and thapsigargin-evoked Ca2+ entry and protein-tyrosine phosphorylation are inhibited by the tyrosine kinase inhibitors genistein and methyl-2,5-dihydroxycinnamate in fura-2-loaded human platelets. | Sargeant, P., et al. 1993. J Biol Chem. 268: 18151-6. PMID: 7688740
- Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor. | Miksicek, RJ. 1994. J Steroid Biochem Mol Biol. 49: 153-60. PMID: 8031711
- Daidzein inhibits insulin- or insulin-like growth factor-1-mediated signaling in cell cycle progression of Swiss 3T3 cells. | Higashi, K. and Ogawara, H. 1994. Biochim Biophys Acta. 1221: 29-35. PMID: 8130274
- Stimulation of pS2 expression by diet-derived compounds. | Sathyamoorthy, N., et al. 1994. Cancer Res. 54: 957-61. PMID: 8313386
- Genistein inhibition of fast Na+ current in uterine leiomyosarcoma cells is independent of tyrosine kinase inhibition. | Kusaka, M. and Sperelakis, N. 1996. Biochim Biophys Acta. 1278: 1-4. PMID: 8611595
Inhibitor of:
C15orf41, C6ST-1, CCDC141, CCL28, CHST9, DSC3, ERRγ, HS3ST3B1, HS3ST4, KRTAP5-11, LHFPL2, LTrp7, MBP, MUP1, Olfr984, Olfr985, Pxmp2, RSP3, SULT1C2, SULT1C3, SULT2A4, SULT2A6, SULT5A1, T2R20, T2R29, TEX101, Tpbpb, Tyrosine Kinase, UBA52, and V1RF5.Activator of:
Abp δ, Abp ε, AFP Receptor, ALDH1A1, CALHM3, Carbonyl reductase 3, CASC5, CASKIN1, CD151, CD5, CNTF, DDX16, DDX30, DDX31, DDX34, DDX37, DDX52, eIF2C4, ER beta, Estrogen Receptor, Flg, FSHR, GABP-β1, Gelsolin, Glut7, HIC-2, IGF-IRβ, IGFBP6, KIAA1324L, KOR-1, MBPH, MEDA-4, MLTK, NAB1, NAGLU, OTTMUSG00000016414, p35, p67-phox, PABPN1, PHF2, PID1, PKD2, PTPε, PTPDC1, RAG1AP1, SCCA1, SGLT-3b, SULT2A1, TCR C β, TSSK 6, TUSC2, UGT1A2, UGT2B36, UGT3A2, ZNF384, ZNF434, and ZP3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Daidzein, 100 mg | sc-24001 | 100 mg | $25.00 | |||
Daidzein, 500 mg | sc-24001A | 500 mg | $75.00 | |||
Daidzein, 5 g | sc-24001B | 5 g | $150.00 |