GCF Activators
GCF Activators are a collection of chemical compounds designed to indirectly augment the functional activity of GCF through various intracellular signaling pathways. Forskolin, by elevating intracellular cAMP levels, indirectly enhances GCF's functional role by activating PKA, which may phosphorylate transcription factors that co-activate with GCF, thus enhancing its transcriptional activity. Similarly, IBMX works by inhibiting the breakdown of cAMP, synergistically increasing cAMP levels along with Forskolin to potentiate GCF activity. Epigallocatechin gallate leverages its kinase inhibitory properties to reduce the phosphorylation of proteins that negatively regulate GCF, thereby indirectly increasing GCF activity. Dibutyryl-cAMP, a cAMP analog, directly stimulates PKA, leading to enhanced phosphorylation states of co-activators or GCF itself.
PMA activates PKC, which can have downstream effects on GCF by modulating factors that interact with it or by direct phosphorylation. LY294002, a PI3K inhibitor, could allow for increased activity or availability of nuclear factors that co-activate with GCF, enhancing its function. PD 98059 and SB203580, by inhibiting MEK and p38 MAPK respectively, may shift signaling dynamics to enhance GCF activity by altering the phosphorylation status of regulatory proteins. Trichostatin A and Sodium Butyrate, as histone deacetylase inhibitors, facilitate a more open chromatin conformation, potentially increasing GCF's access to DNA and enhancing its transcriptional regulation. A23187, by elevating intracellular calcium, could activate calcium-dependent kinases, which may influence the phosphorylation and function of GCF. Lastly, ZM-447439's inhibition of Aurora kinase may affect cell cycle progression, thereby indirectly modulating the functional activity of GCF by influencing the availability of regulatory proteins.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP levels can enhance GCF (GCFC2) activation by promoting the PKA-mediated phosphorylation of transcription factors that co-activate with GCF, thus enhancing its transcriptional activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP. By maintaining higher levels of cAMP, IBMX can synergize with Forskolin to potentiate the PKA signaling pathway, indirectly enhancing the activity of GCF. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This polyphenol inhibits various kinases, which might decrease the phosphorylation of proteins that compete with or negatively regulate GCF, thus enhancing GCF's functional activity in the nucleus. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a membrane-permeable cAMP analog that directly activates PKA. By activating PKA, it may enhance GCF by promoting the phosphorylation of proteins that interact with or co-activate GCF. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC). PKC activation can lead to downstream effects that enhance GCF activity by modulating the nuclear factors that interact with GCF or by phosphorylating GCF itself. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that could indirectly enhance GCF activity. By inhibiting PI3K, it may reduce the activity of downstream AKT, potentially allowing factors that co-activate or interact with GCF to be more active or available in the nucleus. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A MEK inhibitor that can lead to reduced ERK pathway activity. This reduction might enhance GCF activity by altering the phosphorylation status of proteins that interact with or regulate GCF function. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can lead to a more open chromatin structure. An open chromatin structure may enhance GCF activity by facilitating access to DNA for transcription factor complexes that include GCF. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinase, which could enhance GCF by modifying the phosphorylation status of proteins interacting with GCF. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that might enhance GCF by shifting the signaling equilibrium, potentially increasing the availability of co-activators or reducing the phosphorylation of inhibitory proteins that regulate GCF. | ||||||