GABP-α Activators
GABP-α Activators belong to a specialized category of chemical compounds designed to modulate the activity of the GA-binding protein alpha subunit (GABP-α), also known as nuclear respiratory factor 2 (NRF-2). GABP-α is a transcription factor that plays a critical role in the regulation of nuclear genes encoding mitochondrial proteins. Mitochondria are essential organelles responsible for various cellular processes, including energy production through oxidative phosphorylation, and they rely on a coordinated interplay between nuclear and mitochondrial genomes to function properly. GABP-α serves as a central player in this coordination by controlling the expression of nuclear genes encoding mitochondrial proteins.
GABP-α Activators are compounds engineered to interact with GABP-α and influence its transcriptional activity. These activators can either enhance or inhibit the binding of GABP-α to its target genes, depending on their chemical structure and mode of action. By targeting GABP-α, these compounds provide researchers with a tool to investigate the precise mechanisms by which GABP-α governs the expression of nuclear genes encoding mitochondrial proteins. The study of GABP-α Activators is pivotal for advancing our understanding of how cells regulate mitochondrial biogenesis, maintain mitochondrial function, and adapt to changes in energy demands. Additionally, it offers insights into the broader implications of mitochondrial dysfunction in various diseases and cellular processes, shedding light on the intricate interplay between the nucleus and mitochondria in cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels, which can influence a range of transcription factors. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Br-cAMP is a cell-permeable cAMP analog that activates PKA. Activated PKA phosphorylates various substrates including transcription factors that collaborate with GABP-α, leading to enhanced recruitment of GABP-α to its target gene promoters and increased transcriptional activity, promoting cell survival and proliferation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium levels, potentially impacting signaling pathways that regulate transcription factor activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is known to activate Protein Kinase C (PKC), which can influence various transcription factors including members of the ETS family. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the insulin receptor, triggering signaling pathways that can impact transcription factor function. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor known to activate stress-activated protein kinases (SAPKs) like JNK. Activation of JNK leads to the phosphorylation of transcriptional regulators that can associate with GABP-α, facilitating its binding to DNA and activation of gene expression, particularly genes related to stress response and apoptosis. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $245.00 | 9 | |
Bryostatin 1 binds to and modulates protein kinase C (PKC), which phosphorylates substrates that assist in the recruitment of GABP-α to its target promoters, effectively increasing GABP-α′s transcriptional activity on genes involved in cell cycle control and differentiation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid binds to its nuclear receptors, which can heterodimerize with other transcription factors and bind to retinoic acid response elements (RARE) on DNA. The binding of these receptors can modulate chromatin structure and recruit coactivators to the DNA, facilitating GABP-α binding and transcriptional activation of genes involved in development and differentiation. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $31.00 $117.00 $918.00 | 136 | |
DMSO can induce differentiation in certain cell types, leading to altered gene expression profiles. This differentiation process can involve the upregulation of specific kinases or coactivators that enhance GABP-α activity, promoting its role in the transcriptional regulation of genes involved in differentiation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a stable cAMP analog that activates PKA. PKA can phosphorylate regulatory proteins that synergize with GABP-α, augmenting its transcriptional activity towards genes associated with cell metabolism and survival pathways. | ||||||