GABP-α Inhibitors
GABP-α inhibitors belong to a specific chemical class of compounds that exert their biological effects by targeting and modulating the activity of the GABP-α transcription factor. GABP-α, or GA-binding protein alpha, is a crucial transcription factor that plays a central role in regulating the expression of various genes involved in cellular processes such as proliferation, differentiation, and metabolism. Inhibitors of GABP-α are designed to interfere with the binding of this transcription factor to its target DNA sequences, thereby disrupting its ability to activate gene expression. This class of compounds represents a promising area of research in the field of molecular biology due to its ability to manipulate gene expression patterns and impact cellular functions.
The mechanism of action of GABP-α inhibitors typically involves the binding of these compounds to specific regions of the GABP-α protein, often at the DNA-binding domain or other critical interaction sites. By binding to GABP-α, these inhibitors can prevent its interaction with DNA and thereby inhibit the transcriptional activation of target genes. This interference with gene expression can have far-reaching consequences on various cellular pathways, making GABP-α inhibitors valuable tools for understanding the regulatory networks that govern cell behavior. Researchers are actively exploring the development and optimization of GABP-α inhibitors to uncover their full potential in deciphering molecular mechanisms within cells and identifying novel applications in the future.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to modulate various signaling pathways and transcription factors. Its potential role in inhibiting GABP-α may be through its anti-inflammatory and antioxidant properties. | ||||||
LY3214996 | 1951483-29-6 | sc-507299 | 5 mg | $265.00 | ||
LY3214996 is an ERK1 and ERK2 inhibitor, which interrupts the MAPK/ERK pathway. Since GABP-α is a downstream transcription factor activated by the ERK pathway, inhibiting upstream ERK1/2 results in reduced transcriptional activity of GABP-α by limiting its phosphorylation and thereby its DNA-binding capacity, influencing gene expression regulated by GABP-α. | ||||||
PF 477736 | 952021-60-2 | sc-362781 sc-362781A | 5 mg 25 mg | $115.00 $431.00 | ||
PF-477736 is a selective checkpoint kinase 1 (Chk1) inhibitor. Chk1 is involved in DNA damage response and cell cycle control. GABP-α regulates genes essential for cell cycle progression; hence, Chk1 inhibition by PF-477736 can disrupt cell cycle-regulated gene expression mediated by GABP-α, particularly affecting its role in the transition from G1 to S phase. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to influence several signaling pathways and might modulate GABP-α indirectly through its effects on cellular aging, inflammation, and oxidative stress. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane has been shown to have various biological effects, including modulation of transcription factors. Its potential effect on GABP-α could be through its role in cellular detoxification. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
PD 0332991 disrupts cell cycle progression by preventing retinoblastoma (Rb) phosphorylation. This inhibition leads to reduced E2F transcription factor activity, which can indirectly affect GABP-α activity since GABP-α is known to regulate some genes in concert with E2F during the G1/S phase transition. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
(-)-Epigallocatechin Gallate is a major component of green tea and has various biological activities. It might affect GABP-α expression indirectly through its anti-inflammatory and antioxidant properties. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
Alisertib inhibits Aurora A kinase, a protein that contributes to cell cycle progression, especially at the G2/M transition. By inhibiting Aurora A, Alisertib impedes the entry into mitosis, indirectly affecting GABP-α′s ability to regulate genes associated with mitotic entry and progression, since GABP-α can control the expression of genes necessary for this cell cycle phase. | ||||||
Trametinib | 871700-17-3 | sc-364639 sc-364639A sc-364639B | 5 mg 10 mg 1 g | $114.00 $166.00 $947.00 | 19 | |
Trametinib is a MEK inhibitor that impairs the MEK-ERK signaling cascade. Inhibition of MEK leads to reduced activation of ERK, which is necessary for the phosphorylation and subsequent activation of GABP-α. Thus, trametinib indirectly suppresses GABP-α activity by decreasing the transcription of ERK-dependent genes that are targets of GABP-α. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties, and it has been shown to modulate various signaling pathways. Its potential role in inhibiting GABP-α may be through its effects on cellular stress responses. | ||||||