FLRT1 Inhibitors
FLRT1 inhibitors belong to a class of small molecules or biological agents that are designed to modulate the activity of the Fibronectin Leucine-Rich Transmembrane Protein 1 (FLRT1). FLRT1 is part of a family of three proteins (FLRT1, FLRT2, FLRT3) that are involved in various cellular processes, including adhesion, signaling, and cell migration. These proteins possess extracellular leucine-rich repeat domains and transmembrane regions, which allow them to interact with other cellular receptors and ligands. FLRT1, specifically, is known to regulate cell adhesion and repulsion mechanisms through interactions with other proteins like UNC5, a receptor involved in axon guidance and tissue morphogenesis. By inhibiting FLRT1, researchers can manipulate cellular behaviors such as migration and adhesion, making these inhibitors valuable for studying various aspects of cellular biology.
The biochemical nature of FLRT1 inhibitors typically involves disrupting the interaction between FLRT1 and its binding partners, either by binding directly to FLRT1 or by inhibiting associated pathways that regulate its activity. These inhibitors can vary in their molecular structure, ranging from small organic molecules to peptides or antibodies that target specific domains of FLRT1. Studies involving FLRT1 inhibitors often focus on their role in modulating cellular dynamics, including the reorganization of the cytoskeleton and changes in cell morphology. The precise control of FLRT1 activity through inhibition allows scientists to explore its function in development, cell positioning, and tissue organization, helping to unravel the broader biological roles of FLRT family proteins. Understanding these inhibitors contributes significantly to the study of protein-protein interactions and their implications in fundamental biological processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 may downregulate FLRT1 expression by inhibiting the PI3K/AKT pathway, leading to a decrease in the transcriptional activity of genes that rely on this pathway for expression, potentially including FLRT1. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
By blocking MEK1/2 activity, PD 98059 could reduce the phosphorylation of ERK1/2, a process necessary for the transcription of certain genes, which may result in the reduced expression of FLRT1. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB 431542 might decrease FLRT1 expression by selectively inhibiting TGF-β receptor kinases, thereby attenuating the TGF-β signaling that can drive the transcription of genes like FLRT1. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
DAPT, by inhibiting γ-secretase, can prevent the cleavage and activation of Notch receptors, potentially leading to the decreased transcription of Notch target genes, potentially including FLRT1. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 could lead to a decrease in FLRT1 expression by specifically inhibiting MEK, which is upstream of ERK in the MAPK pathway, a pathway that can control the transcription of numerous genes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may downregulate FLRT1 expression by inhibiting the activation of transcription factors such as NF-κB and AP-1, which are known to drive the transcription of various genes, including FLRT1. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin could reduce the expression of FLRT1 by inhibiting the phosphorylation of STAT3, a transcription factor directly involved in the transcription of numerous genes, thereby reducing their expression levels. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol might suppress FLRT1 transcription by activating SIRT1, which deacetylates transcription factors and histone proteins, leading to changes in gene expression profiles, including the downregulation of FLRT1. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane may downregulate FLRT1 by activating NRF2, which then translocates to the nucleus and binds to antioxidant response elements (AREs) in the promoters of target genes, potentially repressing FLRT1 transcription. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin might decrease FLRT1 expression by inhibiting casein kinase 2 (CK2), an enzyme involved in the phosphorylation of critical proteins that govern the transcription of genes including FLRT1. | ||||||