Flotillin-2 Activators
Common Flotillin-2 Activators include, but are not limited to Cholesterol CAS 57-88-5, Simvastatin CAS 79902-63-9, Methyl-β-cyclodextrin CAS 128446-36-6, Sphingomyelinase (Staphylococcus aureus) CAS 9031-54-3 and Forskolin CAS 66575-29-9.
Flotillin-2, also known as reggie-1, is a protein that is widely recognized for its role in various cellular processes, especially within the realm of cell signaling and endocytosis. It is a key component of specialized lipid raft microdomains, which are cholesterol and sphingolipid-enriched areas within the plasma membrane. These lipid rafts serve as platforms for the assembly and function of signaling molecules, effectively orchestrating numerous signaling pathways. Flotillin-2, together with its partner protein Flotillin-1, forms hetero-oligomeric complexes that are integral to the structural and functional integrity of these lipid rafts. Beyond this, Flotillin-2 is implicated in the endocytosis process, playing a role in clathrin-independent endocytosis, which is a mechanism cells utilize to internalize various molecules without the involvement of the protein clathrin.
Flotillin-2 Activators are a group of chemical entities that can stimulate or enhance the activity or expression of the Flotillin-2 protein. These activators elevate the transcription or translation of the Flotillin-2 gene, leading to an increase in protein abundance. Alternatively, they might directly enhance its function or stabilize the protein, preventing its degradation. By activating Flotillin-2, these compounds can significantly influence the architecture and dynamics of lipid raft microdomains, modulating various signaling pathways associated with these domains. Furthermore, given Flotillin-2's role in endocytosis, its activation could also impact how cells internalize certain molecules, thereby affecting cellular communication and response. Delving into the intricacies of Flotillin-2 activators offers valuable insights into the complex world of cellular signaling and the broader implications of lipid raft-associated processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $27.00 $2809.00 $129.00 $210.00 $583.00 $88.00 | 11 | |
Cholesterol is crucial for lipid raft formation. Modulating cholesterol levels might influence the expression of lipid raft-associated proteins like Flotillin-2. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
Simvastatin inhibits cholesterol synthesis. Altered cholesterol levels might influence Flotillin-2 expression due to its association with lipid rafts. | ||||||
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $20.00 $48.00 $160.00 $82.00 | 19 | |
This compound depletes cholesterol from membranes, affecting lipid raft dynamics. This might influence Flotillin-2 expression. | ||||||
Sphingomyelinase (Staphylococcus aureus) | 9031-54-3 | sc-471277 | 10 U | $103.00 | ||
By generating ceramide from sphingomyelin, this enzyme can affect lipid raft composition and potentially Flotillin-2 levels. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, modulating cAMP levels and cellular signaling. This might indirectly influence Flotillin-2 expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can modulate various cellular pathways potentially influencing Flotillin-2 expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that affects cellular signaling. It might modulate Flotillin-2 levels by influencing membrane-associated signaling events. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $143.00 $510.00 | 2 | |
This compound disrupts cholesterol transport and can influence lipid raft dynamics, potentially affecting Flotillin-2 expression. | ||||||
2-Hydroxypropyl-β-cyclodextrin | 128446-35-5 | sc-203461 sc-203461B sc-203461C sc-203461A | 1 g 100 g 500 g 5 g | $53.00 $620.00 $1989.00 $133.00 | 8 | |
Like Methyl-β-cyclodextrin, this compound affects cholesterol in membranes, potentially influencing Flotillin-2 levels. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
As a cholesterol-lowering agent, lovastatin might influence the expression of lipid raft-associated proteins like Flotillin-2. | ||||||