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2-Hydroxypropyl-β-cyclodextrin (CAS 128446-35-5) - chemical structure image — Molecular structure of 2-Hydroxypropyl-β-cyclodextrin, CAS Number: 128446-35-5

Molecular structure of 2-Hydroxypropyl-β-cyclodextrin, CAS Number: 128446-35-5

2-Hydroxypropyl-β-cyclodextrin (CAS 128446-35-5)

Name: 2-Hydroxypropyl-&beta;-cyclodextrin | CAS 128446-35-5
Brand: SCBT
SKU: sc-203461
Price: 52.0 USD
Availability: InStock

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Alternate Names:

2-Hydroxypropyl-β-cyclodextrin is also known as Hydroxypropyl-beta-cyclodextrin.

Application:

2-Hydroxypropyl-β-cyclodextrin is a cyclodextrin oligosaccharide that improves the aqueous solubility of various compounds, especially those containing a phenyl group.

CAS Number:

128446-35-5

Purity:

≥98%

Molecular Weight:

1541.54

Molecular Formula:

C₆₃H₁₂O₄₂

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data.

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Technical Information

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SDS & Certificate of Analysis

2-Hydroxypropyl-β-cyclodextrin is the most widely used modified cyclodextrin. 2-Hydroxypropyl-β-cyclodextrin has shown to change the physicochemical properties of lipophilic compounds when co-administered. 2-Hydroxypropyl-β-cyclodextrin functions by forming an inclusion complex with 2-Hydroxypropyl-β-cyclodextrin being administered for easier diffusion across biological membranes. The popularity of 2-Hydroxypropyl-β-cyclodextrin can be attributed to its large 7 glucose unit cavity size. Some advantageous effects are reduction of negative effects, increased aqueous solubility and increased stability. The effects of 2-Hydroxypropyl-β-cyclodextrin have been observed to be dose dependent with both advantageous and disadvantageous results occurring at sporadic concentrations. 2-Hydroxypropyl-β-cyclodextrin may also increase the antimicrobial effectiveness of chemical agents by increasing their release rate. 2-Hydroxypropyl-β-cyclodextrin is also known as Hydroxypropyl-beta-cyclodextrin, (2-Hydroxypropyl)-beta-cyclodextrin, 2-hydroxypropyl ethers β-cyclodextrin, and HP-β-CD.

2-Hydroxypropyl-β-cyclodextrin (CAS 128446-35-5) References

Characterization of the interaction of 2-hydroxypropyl-beta-cyclodextrin with itraconazole at pH 2, 4, and 7. | Peeters, J., et al. 2002. J Pharm Sci. 91: 1414-22. PMID: 12115841
Hydroxypropyl-beta-cyclodextrin can modulate the activity of spinally administered sufentanil. | Meert, TF., et al. 1992. Eur J Anaesthesiol. 9: 399-409. PMID: 1396627
Development and pharmacological evaluation of ropivacaine-2-hydroxypropyl-beta-cyclodextrin inclusion complex. | de Araujo, DR., et al. 2008. Eur J Pharm Sci. 33: 60-71. PMID: 18036789
Structural behaviour of 2-hydroxypropyl-beta-cyclodextrin in water: molecular dynamics simulation studies. | Yong, CW., et al. 2008. Pharm Res. 25: 1092-9. PMID: 18161014
Study of the interaction between hydroxymethylnitrofurazone and 2-hydroxypropyl-beta-cyclodextrin. | Grillo, R., et al. 2008. J Pharm Biomed Anal. 47: 295-302. PMID: 18289821
Effect of beta-cyclodextrin and hydroxypropyl beta-cyclodextrin complexation on physicochemical properties and antimicrobial activity of cefdinir. | Aleem, O., et al. 2008. J Pharm Biomed Anal. 47: 535-40. PMID: 18367363
Comparative interaction of 2-hydroxypropyl-beta-cyclodextrin and sulfobutylether-beta-cyclodextrin with itraconazole: phase-solubility behavior and stabilization of supersaturated drug solutions. | Brewster, ME., et al. 2008. Eur J Pharm Sci. 34: 94-103. PMID: 18420390
The effects of cyclodextrins on the disposition of intravenously injected drugs in the rat. | Frijlink, HW., et al. 1991. Pharm Res. 8: 380-4. PMID: 2052529
Use of 2-hydroxypropyl-beta-cyclodextrin as a solubilizing and stabilizing excipient for protein drugs. | Brewster, ME., et al. 1991. Pharm Res. 8: 792-5. PMID: 2062811
Collaborative development of 2-hydroxypropyl-β-cyclodextrin for the treatment of Niemann-Pick type C1 disease. | Ottinger, EA., et al. 2014. Curr Top Med Chem. 14: 330-9. PMID: 24283970
2-Hydroxypropyl-β-cyclodextrin promotes transcription factor EB-mediated activation of autophagy: implications for therapy. | Song, W., et al. 2014. J Biol Chem. 289: 10211-22. PMID: 24558044
2-Hydroxypropyl-β-Cyclodextrin Acts as a Novel Anticancer Agent. | Yokoo, M., et al. 2015. PLoS One. 10: e0141946. PMID: 26535909
2-Hydroxypropyl-β-Cyclodextrin Aggregates: Identification and Development of Analytical Techniques. | Sá Couto, AR., et al. 2018. Materials (Basel). 11: PMID: 30322145
The mechanism of bensulfuron-methyl complexation with β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin and effect on soil adsorption and bio-activity. | Geng, Q., et al. 2019. Sci Rep. 9: 1882. PMID: 30760785
Ultrasound processed cuminaldehyde/2-hydroxypropyl-β-cyclodextrin inclusion complex: Preparation, characterization and antibacterial activity. | Cui, H., et al. 2019. Ultrason Sonochem. 56: 84-93. PMID: 31101292

Inhibitor of:

1700062C10Rik, ACBD5, Annexin A9, BLOS2, C8orf40, CL-P1, CLRN2, EXOSC (exosome component), HAPLN1, hole, Olfr340, PPT2, protein 4.2, Raftlin-2, SCAMP4, Shigatoxin, SPFH1, TMEM154, TMEM86A, ZBTB (Zinc finger BTB domain containing), and ZBTB1.

Activator of:

BAIAP3, C14orf109, CCDC132, CD175s, connexin 59, Cyclophilin C, DC-SIGN_CD209a, Flotillin-2, GPR137B, HEXA, karyopherin β3, LIMP II, Lyst, MALL, MENTHO, MLN64, NECAP 1, NET-7, NPAL2, O-Ac GD3, OR4C45, Rab 37, Rsph10b2, SCRN2, Sec3, Sprr2k, sulfamidase, and TSPAN2.

Ordering Information

Product Name	Catalog #	UNIT	Price	Qty	FAVORITES
2-Hydroxypropyl-β-cyclodextrin, 1 g	sc-203461	1 g	$52.00
2-Hydroxypropyl-β-cyclodextrin, 5 g	sc-203461A	5 g	$130.00
2-Hydroxypropyl-β-cyclodextrin, 100 g	sc-203461B	100 g	$620.00
2-Hydroxypropyl-β-cyclodextrin, 500 g	sc-203461C	500 g	$1950.00

Do you have a methodology using 2-Hydroxypropyl-β-cyclodextrin to dissolve a lipophilic compound in a aqueous solution?

Asked by: SCM4

The methodology for solubilizing a lipophilic compound in an aqueous solution using 2-Hydroxypropyl-β-cyclodextrin is dependent on the specific compound of interest. Below are some references to help determine the concentration and methodology for the complexation. A lipophilic compound's ability to complex with 2-Hydroxypropyl-β-cyclodextrin is related to the compound's size, shape, and lipid partition coefficient. (Yaksh TL, Jang J, Nishiuchi Y, Braun KP, Ro S & Goodman M. Life Sci 1991;48(7):623-633) For instance, capsaicin, a lipid-soluble compound, was dissolved in 20% 2-Hydroxypropyl-β-cyclodextrin aqueous solution which resulted in a shift of the lipid partition coefficient from 0.01 to 2.05. According to the Research Journal of Pharmaceutical, Biological and Chemical Sciences: "Generally, guest /cyclodextrin complexes have a molar ratio, [guest]/[cyclodextrin] of 1:1. The molar ratio can be higher or lower and this depends on the size of the guest molecule and the identity of the cyclodextrin. Many techniques which are used to form CD-complexes are kneading, co-precipitation, dry mixing, sealing, slurry complexation, neutralization, spray drying, freeze-drying, and solvent evaporation." (Kumar Das, Sanjoy, Rajan Rajabalaya, Sheba David, et. al. "Cyclodextrins-The Molecular Container." Research Journal of Pharmaceutical, Biological and Chemical Sciences 4.2: 1694-720. RJPBCS. RJPBCS. Web)

Answered by: Tech Service 11

Date published: 2020-05-09

Rated 5 out of 5 by SF from BaekBaek, JS. et al. (PubMed 26347363) modified paclitaxel-loaded solid lipid nanoparticles with 2-hydroxypropyl- -cyclodextrin, a cyclodextrin that allows easier diffusion of lipophiles across biological membranes. They found that this modification enhanced absorption and reduced nephrotoxicity associated with intravenous injection. -SCBT Publication Review

Date published: 2015-03-25

2-Hydroxypropyl-β-cyclodextrin is rated 5.0 out of 5 by 1.

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Test	Specification	Results
Appearance	White to off-white powder	White powder
Identification (FTIR)		Complies
Identification (Mass Spectrometry)		Complies
Purity (HPLC/ELSD)		99.6%
Melting Point		259-267oC
Optical Rotation		+135.0o (c=1 in H2O)

2-Hydroxypropyl-β-cyclodextrin (CAS 128446-35-5)

2-Hydroxypropyl-β-cyclodextrin (CAS 128446-35-5) References

SAMPLE Certificate of Analysis (COA)

How to request a Certificate of Analysis (COA) when it is not available online?

2-Hydroxypropyl-β-cyclodextrin, 1 g

2-Hydroxypropyl-β-cyclodextrin, 5 g

2-Hydroxypropyl-β-cyclodextrin, 100 g

2-Hydroxypropyl-β-cyclodextrin, 500 g

Do you have a methodology using 2-Hydroxypropyl-β-cyclodextrin to dissolve a lipophilic compound in a aqueous solution?

2-Hydroxypropyl-β-cyclodextrin (CAS 128446-35-5)

2-Hydroxypropyl-β-cyclodextrin (CAS 128446-35-5) References

SAMPLE Certificate of Analysis (COA)

How to request a Certificate of Analysis (COA) when it is not available online?

2-Hydroxypropyl-β-cyclodextrin, 1 g

2-Hydroxypropyl-β-cyclodextrin, 5 g

2-Hydroxypropyl-β-cyclodextrin, 100 g

2-Hydroxypropyl-β-cyclodextrin, 500 g

Do you have a methodology using 2-Hydroxypropyl-&beta;-cyclodextrin to dissolve a lipophilic compound in a aqueous solution?

Do you have a methodology using 2-Hydroxypropyl-β-cyclodextrin to dissolve a lipophilic compound in a aqueous solution?