FKHRL1 Activators
FKHRL1, also known as FOXO3a, is a transcription factor belonging to the FOXO (Forkhead box O) family of proteins. Its primary function is to regulate gene expression in response to various cellular signals, thereby playing crucial roles in diverse biological processes such as cell cycle regulation, apoptosis, DNA repair, oxidative stress response, and longevity. FKHRL1 exerts its effects by binding to specific DNA sequences in the promoter regions of target genes, thereby modulating their transcriptional activity. Through these mechanisms, FKHRL1 plays a pivotal role in maintaining cellular homeostasis and responding to environmental stressors.
The activation of FKHRL1 is tightly regulated by multiple signaling pathways, with phosphorylation being a key mechanism of activation. In its inactive state, FKHRL1 resides predominantly in the cytoplasm, where it is phosphorylated by various protein kinases such as AKT, SGK, and MST1. Phosphorylation leads to the inhibition of FKHRL1's transcriptional activity by promoting its interaction with 14-3-3 proteins, which sequester FKHRL1 in the cytoplasm and prevent its nuclear localization. However, under conditions of cellular stress or in response to specific signals, such as growth factor deprivation or oxidative stress, FKHRL1 becomes dephosphorylated. Dephosphorylation allows FKHRL1 to translocate into the nucleus, where it can bind to its target genes' promoters and regulate their transcription, thereby exerting its biological effects. Additionally, FKHRL1 activity can be modulated by various post-translational modifications, including acetylation, ubiquitination, and methylation, further adding to the complexity of its regulation and activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAPK, indirectly activating FKHRL1. By inhibiting p38 MAPK signaling, it prevents the inhibitory phosphorylation of FKHRL1, leading to increased FKHRL1 transcriptional activity and enhanced cellular functions. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3-kinase inhibitor that indirectly activates FKHRL1. By inhibiting PI3-kinase, it disrupts the AKT signaling pathway, preventing the inhibitory phosphorylation of FKHRL1 and leading to increased FKHRL1 activity and nuclear translocation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a selective PI3-kinase inhibitor that indirectly activates FKHRL1. Similar to Wortmannin, it disrupts the AKT signaling pathway, releasing the inhibitory control on FKHRL1 and allowing for increased transcriptional activity and cellular functions. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective JNK inhibitor that indirectly activates FKHRL1. By inhibiting JNK signaling, it prevents the inhibitory phosphorylation of FKHRL1, leading to increased transcriptional activity and enhanced cellular functions mediated by FKHRL1. | ||||||
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 | 612847-09-3 | sc-202048 sc-202048A | 1 mg 5 mg | $204.00 $265.00 | 29 | |
Akt Inhibitor VIII is a selective Akt inhibitor that indirectly activates FKHRL1. By inhibiting Akt signaling, it prevents the inhibitory phosphorylation of FKHRL1, leading to increased FKHRL1 transcriptional activity and enhanced cellular functions. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective MEK1 inhibitor that indirectly activates FKHRL1. By inhibiting the MAPK/ERK pathway, it prevents the inhibitory phosphorylation of FKHRL1, leading to increased FKHRL1 transcriptional activity and enhanced cellular functions. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
SB216763 is a GSK-3 inhibitor that indirectly activates FKHRL1. By inhibiting GSK-3, it stabilizes β-catenin, which in turn enhances FKHRL1 transcriptional activity. This mechanism favors the nuclear translocation of FKHRL1, promoting its activation. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 is a selective inhibitor of the TGF-β type I receptor ALK5, indirectly activating FKHRL1. By blocking the TGF-β signaling pathway, it prevents the inhibitory phosphorylation of SMAD2/3 on FKHRL1, leading to increased FKHRL1 transcriptional activity. | ||||||
JAK Inhibitor I | 457081-03-7 | sc-204021 sc-204021A | 500 µg 1 mg | $153.00 $332.00 | 59 | |
JAK Inhibitor I is a selective JAK inhibitor that indirectly activates FKHRL1. By inhibiting JAK signaling, it prevents the inhibitory phosphorylation of FKHRL1, leading to increased FKHRL1 transcriptional activity and enhanced cellular functions. | ||||||
LY 303511 | 154447-38-8 | sc-202215 sc-202215A | 1 mg 5 mg | $66.00 $273.00 | 3 | |
LY303511 is a selective PI3-kinase inhibitor that indirectly activates FKHRL1. Similar to LY294002 and Wortmannin, it disrupts the AKT signaling pathway, releasing the inhibitory control on FKHRL1 and allowing for increased transcriptional activity and functions. | ||||||