Fhit Activators
Fhit, also known as fragile histidine triad protein, is a tumor suppressor protein that plays a crucial role in safeguarding genomic integrity and suppressing tumorigenesis. Its primary function involves the hydrolysis of dinucleoside polyphosphates, such as Ap3A and Ap4A, which are involved in regulating various cellular processes, including cell proliferation and apoptosis. Through its enzymatic activity, Fhit controls the levels of these dinucleoside polyphosphates, thereby modulating signaling pathways critical for cell cycle progression and cell survival. By regulating these pathways, Fhit exerts tumor-suppressive effects, preventing the accumulation of genetic alterations and inhibiting the growth of cancer cells.
Activation of Fhit involves various mechanisms aimed at restoring or enhancing its tumor-suppressive functions. One common mechanism of activation is through the upregulation of Fhit expression at the transcriptional or translational level. This can be achieved through the activation of specific transcription factors or the removal of epigenetic modifications that repress Fhit gene expression. Additionally, post-translational modifications such as phosphorylation or acetylation may enhance Fhit activity, leading to increased hydrolysis of dinucleoside polyphosphates and subsequent modulation of downstream signaling pathways. Furthermore, activation of signaling pathways associated with cellular stress or DNA damage response may also stimulate Fhit activity, allowing it to exert its tumor-suppressive functions more effectively. Overall, understanding the mechanisms of Fhit activation is crucial for developing strategies to harness its tumor-suppressive properties for interventions in cancer.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate is a short-chain fatty acid that acts as a histone deacetylase inhibitor. By inhibiting histone deacetylases, Sodium Butyrate modulates chromatin structure and enhances Fhit expression through epigenetic mechanisms, promoting an open chromatin state that facilitates transcription of the Fhit gene. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a potent histone deacetylase inhibitor that induces hyperacetylation of histones. Through its action on histone deacetylases, Trichostatin A promotes an open chromatin structure, leading to increased transcription of the Fhit gene and subsequent upregulation of Fhit expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2'-Deoxycytidine is a nucleoside analog and DNA methyltransferase inhibitor. By inhibiting DNA methyltransferases, this compound demethylates the Fhit gene promoter, leading to enhanced transcriptional activity and increased expression of Fhit. The demethylation of the Fhit promoter contributes to the activation of Fhit in cellular contexts. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a polyphenolic compound known for its diverse biological effects. It activates AMP-activated protein kinase (AMPK), a key cellular energy sensor. By activating AMPK, Resveratrol influences cellular energy balance and signaling pathways, potentially leading to modulation of Fhit expression or function through AMPK-mediated regulatory mechanisms. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a natural polyphenol, is known for its anti-inflammatory and antioxidant properties. It activates AMP-activated protein kinase (AMPK), influencing cellular energy balance. Through AMPK activation, Curcumin may modulate Fhit expression or function by impacting cellular energy-related pathways and contributing to the regulatory network governing Fhit activity. | ||||||
5-Bromo-2′-deoxyuridine | 59-14-3 | sc-290815 sc-290815A sc-290815B sc-290815C sc-290815D | 50 mg 250 mg 500 mg 1 g 5 g | $49.00 $77.00 $83.00 $126.00 $589.00 | ||
5-Bromo-2'-deoxyuridine is a thymidine analog that incorporates into DNA during replication. Its incorporation can activate the DNA damage response, leading to cell cycle arrest and increased expression of Fhit as part of cellular responses to DNA damage. This compound may indirectly activate Fhit by triggering DNA damage signaling pathways. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $31.00 $83.00 | 6 | |
Theophylline is a phosphodiesterase inhibitor that increases intracellular levels of cyclic AMP (cAMP). Elevated cAMP levels can activate protein kinase A (PKA), which may, in turn, influence cellular signaling pathways and contribute to the modulation of Fhit expression or function. Theophylline's impact on cAMP-dependent pathways presents a potential mechanism for Fhit activation. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid, a histone deacetylase inhibitor, modulates chromatin structure by inhibiting histone deacetylases. Through this mechanism, Valproic Acid promotes an open chromatin state, facilitating the transcription of the Fhit gene and increasing Fhit expression. The epigenetic regulation induced by Valproic Acid contributes to the activation of Fhit. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea is an inhibitor of ribonucleotide reductase, impacting DNA synthesis. By influencing nucleotide pools and DNA replication, Hydroxyurea may activate the DNA damage response, leading to increased Fhit expression as part of cellular responses to DNA damage. This compound may indirectly activate Fhit by triggering DNA damage signaling pathways. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid is a histone deacetylase inhibitor that modulates chromatin structure by inhibiting histone deacetylases. Through this mechanism, Vorinostat promotes an open chromatin state, facilitating the transcription of the Fhit gene and increasing Fhit expression. The epigenetic regulation induced by Vorinostat contributes to the activation of Fhit in cellular contexts. | ||||||