Fhit Inhibitors
Fhit, or fragile histidine triad protein, is a tumor suppressor protein implicated in various cellular processes, particularly in the maintenance of genomic stability and prevention of tumorigenesis. Its primary function revolves around the hydrolysis of dinucleoside polyphosphates such as Ap3A and Ap4A, which are involved in signaling pathways related to cell proliferation and apoptosis. Fhit's enzymatic activity plays a crucial role in regulating these signaling pathways by controlling the levels of these dinucleoside polyphosphates, thereby exerting tumor-suppressive effects.
Inhibition of Fhit activity can disrupt its tumor-suppressive functions and contribute to tumorigenesis. Several mechanisms can lead to Fhit inhibition, including genetic alterations such as mutations or deletions that impair Fhit expression or function. Additionally, epigenetic modifications such as DNA methylation or histone acetylation may silence Fhit expression, further inhibiting its tumor-suppressive effects. Furthermore, dysregulation of upstream signaling pathways or interactions with other proteins may also lead to Fhit inhibition. For example, overexpression of certain oncogenes or aberrant activation of growth factor signaling pathways can downregulate Fhit expression or activity, promoting tumor development. Overall, inhibition of Fhit represents a critical step in tumorigenesis, highlighting its significance as a target for intervention in cancer research.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Fluorouracil is a pyrimidine analog that interferes with nucleic acid synthesis. By inhibiting thymidylate synthase, it disrupts the de novo synthesis of thymidine, affecting DNA replication. This disruption in DNA synthesis can indirectly modulate Fhit by altering cellular processes reliant on accurate DNA replication. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate inhibits dihydrofolate reductase, disrupting folate metabolism and nucleotide synthesis. By interfering with these essential cellular processes, Methotrexate indirectly influences Fhit through downstream effects on DNA replication and repair pathways dependent on adequate nucleotide pools. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor, preventing DNA unwinding and replication. Through its action on topoisomerase I, Camptothecin indirectly modulates Fhit by disrupting DNA replication processes, leading to alterations in cellular pathways dependent on accurate DNA synthesis. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
Also called Gemcitabine, this compound is incorporated into DNA during replication, leading to chain termination. By disrupting DNA synthesis, Gemcitabine indirectly influences Fhit by altering cellular processes dependent on accurate DNA replication and repair. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $42.00 $54.00 | 3 | |
6-Thioguanine is a purine analog that interferes with nucleic acid synthesis. By incorporating into DNA during replication, it disrupts the structure and function of DNA. This disruption in DNA synthesis can indirectly modulate Fhit by altering cellular processes reliant on accurate DNA replication and repair. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin is a platinum-containing chemotherapeutic agent that forms DNA adducts, leading to DNA damage and cell death. Through its ability to induce DNA damage, Cisplatin indirectly influences Fhit by activating DNA repair pathways and modulating cellular responses to genotoxic stress. | ||||||
(+)-Irinotecan | 97682-44-5 | sc-269253 | 10 mg | $62.00 | 1 | |
Irinotecan is a topoisomerase I inhibitor, preventing DNA unwinding and replication. Through its action on topoisomerase I, Irinotecan indirectly modulates Fhit by disrupting DNA replication processes, leading to alterations in cellular pathways dependent on accurate DNA synthesis. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide is a topoisomerase II inhibitor, preventing DNA unwinding and replication. By inhibiting topoisomerase II, Etoposide disrupts DNA replication processes, leading to alterations in cellular pathways dependent on accurate DNA synthesis. This disruption can indirectly modulate Fhit through its effects on DNA replication and repair. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules, preventing their depolymerization and disrupting cell division. Through its action on microtubules, Paclitaxel indirectly modulates Fhit by altering cell cycle progression and potentially affecting cellular processes reliant on accurate cell division. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin is an anthracycline antibiotic that intercalates with DNA, leading to DNA damage and cell death. By inducing DNA damage, Doxorubicin indirectly influences Fhit by activating DNA repair pathways and modulating cellular responses to genotoxic stress. | ||||||