FGF-15 Activators
The chemical class of FGF-15 activators encompasses a diverse array of compounds that intricately modulate the pathways associated with FGF-15 activation. Forskolin, a potent activator of adenylate cyclase leading to increased cAMP levels, indirectly stimulates FGF-15 through the elevation of cAMP and subsequent activation of protein kinase A (PKA). This cascading effect influences FGF-15 by modulating the pathways where cAMP/PKA intersects with FGF-15 signaling. GW5074, a small molecule inhibitor of c-Raf kinase, indirectly activates FGF-15 by enhancing the ERK1/2 pathway. Its influence on c-Raf contributes to the activation of downstream pathways involving FGF-15, highlighting the complex network of signaling events leading to FGF-15 activation. Epidermal Growth Factor (EGF) and Phorbol 12-myristate 13-acetate (PMA) activate the EGFR and PKC pathways, respectively, indirectly influencing FGF-15 by modulating shared downstream signaling cascades. The cross-talk between EGFR and FGF-15 pathways, in the case of EGF, and the modulation of PKC-dependent pathways, in the case of PMA, contributes to the activation of FGF-15. Histone modifiers, such as BIX 01294 and Trichostatin A (TSA), indirectly activate FGF-15 by influencing epigenetic regulation.
Metabolic regulators A769662 and 2-Deoxy-D-glucose (2-DG) influence FGF-15 activation through distinct mechanisms. A769662, an AMP-activated protein kinase (AMPK) activator, enhances the AMPK pathway, contributing to the activation of downstream pathways involving FGF-15. 2-DG, an inhibitor of glycolysis, activates FGF-15 by altering cellular energy status and modulating metabolic pathways interconnected with FGF-15. Additionally, Apigenin and PD98059 indirectly activate FGF-15 by influencing the PI3K/Akt and MAPK/ERK pathways, respectively. Apigenin, a flavonoid, stimulates the PI3K/Akt pathway, and PD98059, a MEK1 inhibitor, prevents negative regulation from the MAPK/ERK pathway, collectively illustrating the diverse molecular mechanisms involved in FGF-15 activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 is a small molecule inhibitor of c-Raf kinase, indirectly activating FGF-15 by enhancing the ERK1/2 pathway. Its influence on c-Raf contributes to the activation of downstream pathways involving FGF-15. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin stimulates adenylate cyclase, leading to increased cAMP levels. This elevation in cAMP activates PKA, indirectly activating FGF-15 through the modulation of pathways where cAMP/PKA intersects with FGF-15 signaling. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 free base | sc-202651 | 5 mg | $148.00 | 4 | |
BIX 01294 is a G9a histone methyltransferase inhibitor that indirectly activates FGF-15 by epigenetic regulation. By modulating chromatin structure, it can influence the expression of genes associated with FGF-15 activation. | ||||||
JNK Inhibitor VIII | 894804-07-0 | sc-202673 | 5 mg | $267.00 | 2 | |
JNK Inhibitor VIII inhibits JNK, leading to the activation of FGF-15 through the prevention of its negative regulation. This inhibitor indirectly stimulates FGF-15 by blocking the inhibitory signals from the JNK pathway. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB 431542 is a TGF-β receptor inhibitor, indirectly activating FGF-15 by disrupting the inhibitory signals from TGF-β pathways. Its action releases the negative regulation on FGF-15, contributing to its activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), indirectly activating FGF-15 through the modulation of downstream pathways where PKC intersects with FGF-15 signaling. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
A769662 is an AMP-activated protein kinase (AMPK) activator, indirectly activating FGF-15 by enhancing the AMPK pathway. Its influence on AMPK contributes to the activation of downstream pathways involving FGF-15. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-DG inhibits glycolysis, leading to the activation of FGF-15 through the modulation of cellular energy status. Its action on glycolysis indirectly influences FGF-15 by altering the metabolic pathways interconnected with FGF-15. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA is a histone deacetylase (HDAC) inhibitor that indirectly activates FGF-15 by influencing epigenetic regulation. By inhibiting HDAC, TSA can modulate chromatin structure, affecting the expression of FGF-15. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin is a flavonoid that activates the PI3K/Akt pathway, indirectly activating FGF-15 through the modulation of downstream pathways where PI3K/Akt intersects with FGF-15 signaling. | ||||||