FGF-15 Antibody (D-9): sc-514647
- FGF-15 Antibody (D-9) is a mouse monoclonal IgG2a κ FGF-15 antibody, cited in 16 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 194-218 near the C-terminus of FGF-15 of mouse origin
- FGF-15 Antibody (D-9) is recommended for detection of precursor and mature FGF-15 of mouse origin by WB, IP, IF, IHC(P) and ELISA
- Anti-FGF-15 Antibody (D-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FGF-15 Antibody (D-9) for WB and IHC(P) applications. These reagents are now offered in bundles with FGF-15 Antibody (D-9) (see ordering information below).
FGF-15 Antibody (D-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects FGF-15 protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). FGF-15 (D-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FGF-15 protein plays a crucial role in regulating intestinal homeostasis and participates in signaling pathways that control cell proliferation and differentiation. FGF-15 protein is primarily expressed in the intestine and maintains the balance of gut epithelial cells, which is vital for proper digestive function and overall gut health. Dysregulation of FGF-15 protein has been implicated in various gastrointestinal disorders, making FGF-15 an important target for research and therapeutic interventions. Anti-FGF-15 antibody (D-9) enables researchers to gain insights into FGF-15 biological functions and potential implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FGF-15 Antibody (D-9) References:
- Regulation of Fgf15 expression in the intestine by glucocorticoid receptor. | Jia, K., et al. 2019. Mol Med Rep. 19: 2953-2959. PMID: 30720089
- FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis. | Ji, S., et al. 2019. Dev Cell. 48: 460-474.e9. PMID: 30745141
- Pharmacologic Modulation of Bile Acid-FXR-FGF15/FGF19 Pathway for the Treatment of Nonalcoholic Steatohepatitis. | Schumacher, JD. and Guo, GL. 2019. Handb Exp Pharmacol. 256: 325-357. PMID: 31201553
- FGF15 improves outcomes after brain dead donor liver transplantation with steatotic and non-steatotic grafts in rats. | Gulfo, J., et al. 2020. J Hepatol. 73: 1131-1143. PMID: 32422221
- FGF15/19 is required for adipose tissue plasticity in response to thermogenic adaptations. | Morón-Ros, S., et al. 2021. Mol Metab. 43: 101113. PMID: 33171307
- Feeding activates FGF15-SHP-TFEB-mediated lipophagy in the gut. | Seok, S., et al. 2022. EMBO J. 41: e109997. PMID: 35686465
- Minocycline-induced disruption of the intestinal FXR/FGF15 axis impairs osteogenesis in mice. | Carson, MD., et al. 2023. JCI Insight. 8: PMID: 36413391
- Roseburia intestinalis relieves intrahepatic cholestasis of pregnancy through bile acid/FXR-FGF15 in rats. | Sun, H., et al. 2023. iScience. 26: 108392. PMID: 38025767
- Ji-Ni-De-Xie ameliorates type 2 diabetes mellitus by modulating the bile acids metabolism and FXR/FGF15 signaling pathway. | Tao, Y., et al. 2024. Front Pharmacol. 15: 1383896. PMID: 38835663
- The role of FGF15/FGF19 in the development of the central nervous system, eyes and inner ears in vertebrates. | Hidalgo-Sánchez, M., et al. 2024. Tissue Cell. 91: 102619. PMID: 39579736
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FGF-15 Antibody (D-9) | sc-514647 | 200 µg/ml | $316.00 | |||
FGF-15 Antibody (D-9): m-IgG Fc BP-HRP Bundle | sc-531183 | 200 µg Ab; 10 µg BP | $354.00 | |||
FGF-15 Antibody (D-9): m-IgGκ BP-HRP Bundle | sc-524799 | 200 µg Ab, 40 µg BP | $354.00 | |||
FGF-15 Antibody (D-9): m-IgG2a BP-HRP Bundle | sc-547716 | 200 µg Ab; 10 µg BP | $354.00 | |||
FGF-15 Antibody (D-9) AC | sc-514647 AC | 500 µg/ml, 25% agarose | $416.00 | |||
FGF-15 Antibody (D-9) HRP | sc-514647 HRP | 200 µg/ml | $316.00 | |||
FGF-15 Antibody (D-9) FITC | sc-514647 FITC | 200 µg/ml | $330.00 | |||
FGF-15 Antibody (D-9) PE | sc-514647 PE | 200 µg/ml | $343.00 | |||
FGF-15 Antibody (D-9) Alexa Fluor® 488 | sc-514647 AF488 | 200 µg/ml | $357.00 | |||
FGF-15 Antibody (D-9) Alexa Fluor® 546 | sc-514647 AF546 | 200 µg/ml | $357.00 | |||
FGF-15 Antibody (D-9) Alexa Fluor® 594 | sc-514647 AF594 | 200 µg/ml | $357.00 | |||
FGF-15 Antibody (D-9) Alexa Fluor® 647 | sc-514647 AF647 | 200 µg/ml | $357.00 | |||
FGF-15 Antibody (D-9) Alexa Fluor® 680 | sc-514647 AF680 | 200 µg/ml | $357.00 | |||
FGF-15 Antibody (D-9) Alexa Fluor® 790 | sc-514647 AF790 | 200 µg/ml | $357.00 | |||
FGF-15 (D-9) Neutralizing Peptide | sc-514647 P | 100 µg/0.5 ml | $68.00 |