FGF-15 Antibody (G-5): sc-398338

FGF-15 (G-5) is a mouse monoclonal IgG2b kappa light chain antibody that detects FGF-15 of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF) and enzyme-linked immunosorbent assay (ELISA). Anti-FGF-15 antibody (G-5) is available non-conjugated, as well as conjugated to agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC) and multiple Alexa Fluor® conjugates. Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. FGFs act by binding and activating specific cell surface receptors containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. FGF-15, a secreted protein expressed mainly in the developing brain, is important for cell division and patterning regulation in specific embryonic brain regions.

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FGF-15 Antibody (G-5) References:

1. Analysis of Fgf15 expression pattern in the mouse neural tube.  |  Gimeno, L., et al. Brain Res Bull. 57: 297-9. PMID: 11922976
2. A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo.  |  Ishibashi, M. and McMahon, AP. 2002. Development. 129: 4807-19. PMID: 12361972
3. Evolutionary conservation of CCND1-ORAOV1-FGF19-FGF4 locus from zebrafish to human.  |  Katoh, M. and Katoh, M. 2003. Int J Mol Med. 12: 45-50. PMID: 12792807
4. Study of Fgf15 gene expression in developing mouse brain.  |  Gimeno, L., et al. 2003. Gene Expr Patterns. 3: 473-81. PMID: 12915315
5. Characterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin.  |  Mansukhani, A., et al. 1992. Proc Natl Acad Sci U S A. 89: 3305-9. PMID: 1373495
6. Mouse FGF15 is the ortholog of human and chick FGF19, but is not uniquely required for otic induction.  |  Wright, TJ., et al. 2004. Dev Biol. 269: 264-75. PMID: 15081372
7. Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.  |  Dionne, CA., et al. 1990. EMBO J. 9: 2685-92. PMID: 1697263
8. beta-Klotho and FGF-15/19 inhibit the apical sodium-dependent bile acid transporter in enterocytes and cholangiocytes.  |  Sinha, J., et al. 2008. Am J Physiol Gastrointest Liver Physiol. 295: G996-G1003. PMID: 18772362
9. Recent developments in the cell biology of basic fibroblast growth factor.  |  Rifkin, DB. and Moscatelli, D. 1989. J Cell Biol. 109: 1-6. PMID: 2545723
10. Endocrine Adiponectin-FGF15/19 Axis in Ethanol-Induced Inflammation and Alcoholic Liver Injury.  |  You, M., et al. 2018. Gene Expr. 18: 103-113. PMID: 29096734
11. Direct and Indirect Effects of Fibroblast Growth Factor (FGF) 15 and FGF19 on Liver Fibrosis Development.  |  Schumacher, JD., et al. 2020. Hepatology. 71: 670-685. PMID: 31206730
12. Intestinal FGF15 regulates bile acid and cholesterol metabolism but not glucose and energy balance.  |  Bozadjieva-Kramer, N., et al. 2024. JCI Insight. 9: PMID: 38587078

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FGF-15 Antibody (G-5) has 14 citations in a variety of scientific publications.

Primary antibodies like Anti-FGF-15 Antibody (G-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FGF-15 Antibody (G-5) Specifications

Alternate Product Name: FGF-15

Product Clone Name: G-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 88-105

Epitope Target: FGF-15

Epitope Species: mouse

Product Reactivity/Detection: FGF-15

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 14 citations in various scientific publications

Available Conjugates/Forms for FGF-15 Antibody (G-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred FGF-15 antibody is FGF-15 Antibody (D-9): sc-514647.