Date published: 2026-6-6

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FGF-15 Inhibitors

FGF-15 inhibitors constitutes a diverse array of compounds meticulously designed to target the intricate pathways associated with FGF-15 activity. These inhibitors exert their effects either directly on FGF receptors or indirectly through shared signaling cascades. Noteworthy among them are selective inhibitors like SB-525334 and PD173074, which intervene in the TGF-β and FGFR pathways, respectively. By doing so, they indirectly influence FGF-15, disrupting cross-talk between these intricate signaling networks. In addition, compounds such as AZD4547, LY2874455, and NVP-BGJ398 take a direct approach by inhibiting FGFR kinase activity. Through this direct modulation, they impact FGF-15 by disrupting the specific pathways where these molecules interact. Furthermore, other compounds like SU5402, AZD2171, and TKI258, exhibiting inhibitory effects on FGFR and other receptors, contribute to the indirect modulation of FGF-15. This indirect influence occurs by disrupting shared downstream signaling components vital to FGF-15 pathways. FGF-15 inhibitors also encompasses selective pan-FGFR inhibitors, including Infigratinib and BGJ398. These compounds directly impede FGFR activity, thereby impacting FGF-15 through the disruption of common signaling cascades. Collectively, these FGF-15 inhibitors offer a nuanced and sophisticated approach to influence its activity.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

TGF-β RI Kinase Inhibitor VIII

356559-20-1sc-203295
2 mg
$100.00
2
(1)

Also called SB-525334, this compound is a selective inhibitor of the TGF-β receptor I (ALK5). By specifically targeting the TGF-β signaling pathway, it indirectly modulates FGF-15 activity by influencing the cross-talk between these pathways.

AZD4547

1035270-39-3sc-364421
sc-364421A
5 mg
10 mg
$198.00
$309.00
6
(1)

AZD4547 is an FGFR kinase inhibitor that directly inhibits FGF receptor activity, suppressing downstream signaling cascades. This compound can modulate FGF-15 by interrupting the FGFR-mediated pathways it is involved in.

PD173074

219580-11-7sc-202610
sc-202610A
sc-202610B
1 mg
5 mg
50 mg
$47.00
$143.00
$680.00
16
(1)

PD173074 is a potent FGFR inhibitor that directly targets FGFR tyrosine kinase activity. Its inhibitory effects on FGFR signaling pathways indirectly impact FGF-15 by disrupting shared components of the signaling cascades.

SU 5402

215543-92-3sc-204308
sc-204308A
1 mg
5 mg
$63.00
$98.00
36
(3)

SU5402 is a small molecule inhibitor of FGFR and VEGFR tyrosine kinase activity. It indirectly influences FGF-15 by disrupting the shared downstream signaling pathways of FGFR and, consequently, FGF-15 activity.

Cediranib

288383-20-0sc-483599
sc-483599A
sc-483599B
5 mg
10 mg
25 mg
$137.00
$220.00
$406.00
(0)

Cediranib is a multi-targeted receptor tyrosine kinase inhibitor with inhibitory effects on FGFR. By targeting the FGFR pathway, it indirectly modulates FGF-15 activity through the disruption of shared downstream signaling components.

BGJ398

872511-34-7sc-364430
sc-364430A
sc-364430B
sc-364430C
5 mg
10 mg
50 mg
100 mg
$216.00
$252.00
$594.00
$1009.00
4
(1)

BGJ398 is a selective pan-FGFR inhibitor that directly hinders FGFR kinase activity. This compound indirectly influences FGF-15 by disrupting the specific signaling pathways where FGFR and FGF-15 interact.

PD 166866

192705-79-6sc-208154
5 mg
$300.00
1
(0)

PD166866 is a selective FGFR inhibitor that directly interferes with FGFR kinase activity. Its inhibitory effects on FGFR signaling pathways indirectly impact FGF-15 by disrupting the shared components of the signaling cascades.

Dovitinib, Free Base

405169-16-6sc-396771
sc-396771A
10 mg
25 mg
$170.00
$350.00
(0)

Dovitinib, Free Base is a multi-targeted receptor tyrosine kinase inhibitor with inhibitory effects on FGFR. By targeting the FGFR pathway, it indirectly modulates FGF-15 activity through the disruption of shared downstream signaling components.

AP 24534

943319-70-8sc-362710
sc-362710A
10 mg
50 mg
$175.00
$983.00
2
(1)

AP 24534 is a multi-targeted tyrosine kinase inhibitor with inhibitory effects on FGFR. By targeting the FGFR pathway, it indirectly modulates FGF-15 activity through the disruption of shared downstream signaling components.